Aminopeptidase N (APN)/CD13 (EC 3.4.11.2) is a transmembrane protease present in a wide
variety of human tissues and cell types (endothelial, epithelial, fibroblast, leukocyte). APN/…

… We showed that the inhibition of the dynamics of actin filaments by cytochalasin D increased
pauses of lysosomes on actin structures, while depolymerization of actin filaments using …

Searching for stimulators of the innate antiviral response is an appealing approach to develop
novel therapeutics against viral infections. Here, we established a cell-based reporter …

… The K d value estimated from this analysis was 0.19 μM, which implies that the drug forms a
… The estimated K d values derived from this analysis are 0.19 μM for unphosphorylated and …

Junctional complexes such as tight junctions (TJ) and adherens junctions are required for
maintaining cell surface asymmetry and polarized transport in epithelial cells. We have shown …

… B–G) Representative images of one control embryo (B and E) and two 62 treated embryos
displaying short tail (C and F) or no axis phenotype (D and G); scale bar: 500 μm. H–J) Global …

… Our results indicated that derivatives 19b−d, which bear a CH 2 COOH group in the 8-position
and two NO 2 substituents in both 2‘- and 3‘-positions, inhibited efficiently APN activity, …

… (C) and (D) dissipation of the mitochondrial transmembrane potential (ΔΨ m ) by respectively
… We are indebted to D Rouillard for her expert FACS analysis. We thank JR Suarez (Aventis …

To further understand the molecular requirements for the antiproliferative activity of flavonoids,
a series of 3-amino-flavones and some of their derivatives were prepared and evaluated …

… D) DNA fragmentation U937 cells treated for 72 h with MY7 or IgG1 (35 μg/ml) or with … (c,
g), or PMA (d, h) were stained with anti‐CD13‐PE (clone SJ1D1; a–d) or anti‐CD64‐FITC (e‐h) …