Objectives: Inhaled colistin is commonly used in patients with cystic fibrosis (CF), but only
limited data are available to define its pharmacokinetic profile. Patients and methods: We …

… c ) − β where S max [ N c M −1 ] is the maximum solid phase particle concentration, d c [L]
is the median diameter of the sand grains, and β [−] is an empirical variable that controls the …

Following intensive discussions, review, alignment of procedures and multiple surveys
among their member companies, the European Bioanalysis Forum (EBF) is providing a …

BACKGROUND: The human cytochrome P450 enzyme CYP3A4 is involved in the
metabolism of many anticancer drugs. Since these drugs are usually administered in a …

… is the solid phase particle concentration [N c M −1 ], and D is the dispersion coefficient [L 2 …
is the first-order detachment coefficient [T −1 ], d c [L] is the median diameter of the soil grains, …

… is to be determined in plasma instead of two metabolites in urine, (c) a single plasma sample
is more easily and more reliably obtained than a urine collection over several hours, and (d…

The present study was conducted to assess a possible in vivo effect of propiverine, an
anticholinergic drug to treat urinary incontinence and related disorders, on the activity of intestinal …

… ) ( d 50 + x d 50 ) − β where d 50 is the median grain size of the soil [L], β [-] is a parameter
which is controlled by the shape of the retention profile, S M m a x is the maximum solid phase …

… Sample preparation consisted of dilution of urine with an aqueous solution of the internal
standard D 4 ‐CP and methanol, and centrifugation. LC/MS/MS detection was performed using …

Background and objective The BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide,
vincristine, procarbazine and prednisone) chemotherapy regimen for the treatment of …