The blood–brain barrier (BBB) prevents drugs' permeability into the brain and limits the
management of brain diseases. Intranasal delivery is a convenient route of drug administration …

Controlled release gastroretentive dosage forms (CR-GRDF) enable prolonged and
continuous input of the drug to the upper parts of the gastrointestinal (GI) tract and improve the …

Because of various pharmacodynamic properties, such as the nonlinearity of the
concentration-effect relationship, activation of feedback homeostatic mechanisms, induction of …

We examined the pharmacokinetic (PK) and pharmacodynamic (PD) rationales to develop
controlled release (CR) formulations of metformin. Unrestrained diabetic rats received the …

Metformin, a commonly used antidiabetic drug, exerts its glucose-lowering effect due to
metabolic activities at several sites of action (biophases), including liver, intestine, muscle cells, …

… The oxygen 1S spectrum in Figure 2 D revealed a peak at 531.2 eV, attributed to the C=O …
the corresponding statistical analysis in Figure 4 D clearly show that folate residues constitute …

Purpose. The purpose of this study was to design novel gastroretentive dosage forms (GRDFs)
based on unfolding multilayer polymeric films, to investigate the mechanism of their …

Intracellularly targeted delivery system based on PLGA nanoparticles decorated with endoplasmic
reticulum (ER)-targeting or control peptides and encapsulating antigenic peptide and …

This work was aimed at improving the absorption of bisphosphonates by targeting carrier
systems in the intestine and the intestinal peptide carrier system (hPEPT1), in particular. C-…

Since its role in the prevention of osteoporosis in humans was proven some 30 years ago,
calcium bioavailability has been the subject of numerous scientific studies. Recent technology …