User profiles for D.R. Brocks
 | Dion BrocksUniversity of Alberta Verified email at ualberta.ca Cited by 6764 |
Stereospecific pharmacokinetics and pharmacodynamics of beta-adrenergic blockers in humans
The beta-blockers comprise a group of drugs that are mostly used to treat cardiovascular
disorders such as hypertension, cardiac arrhythmia, or ischemic heart disease. Each of these …
disorders such as hypertension, cardiac arrhythmia, or ischemic heart disease. Each of these …
Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery
In contrast to many traditional pharmaceutical agents that exhibit a high degree of aqueous
solubility, new drug candidates are frequently highly lipophilic compounds. The aqueous …
solubility, new drug candidates are frequently highly lipophilic compounds. The aqueous …
Clinical pharmacokinetics of ketoprofen and its enantiomers
Ketoprofen, a potent nonsteroidal anti-inflammatory drug (NSAID) of the 2-arylpropionic
acid class, has been used clinically for over 15 years in Europe, and has recently been …
acid class, has been used clinically for over 15 years in Europe, and has recently been …
High‐performance liquid chromatography analysis of curcumin in rat plasma: application to pharmacokinetics of polymeric micellar formulation of curcumin
Z Ma, A Shayeganpour, DR Brocks… - Biomedical …, 2007 - Wiley Online Library
A simple, rapid and reliable high‐performance liquid chromatographic (HPLC) method was
developed and validated for the determination of curcumin in rat plasma. Plasma was …
developed and validated for the determination of curcumin in rat plasma. Plasma was …
[PDF][PDF] Anticholinergic drugs used in Parkinson's disease: An overlooked class of drugs from a pharmacokinetic perspective
DR Brocks - J Pharm Pharm Sci, 1999 - Citeseer
… and Brocks, DR, Disposition of ethopropazine enantiomers in the rat: Tissue distribution
and plasma protein binding. J Pharm Pharmaceu Sci (www.ualberta.ca/~csps), 2: 23-29, 1999. …
and plasma protein binding. J Pharm Pharmaceu Sci (www.ualberta.ca/~csps), 2: 23-29, 1999. …
Multiple peaking phenomena in pharmacokinetic disposition
multiple peaking in the blood fluid concentration-time curve is a phenomenon occasionally
encountered in pharmacokinetics. When it occurs, it can create difficulties in the …
encountered in pharmacokinetics. When it occurs, it can create difficulties in the …
Drug disposition in three dimensions: an update on stereoselectivity in pharmacokinetics
DR Brocks - Biopharmaceutics & drug disposition, 2006 - Wiley Online Library
… Brocks DR. Stereoselective halofantrine and desbutylhalofantrine disposition in the rat:
cardiac and plasma concentrations and plasma protein binding. Biopharm Drug Dispos 2002; 23…
cardiac and plasma concentrations and plasma protein binding. Biopharm Drug Dispos 2002; 23…
Phase 1 trial of everolimus plus sunitinib in patients with metastatic renal cell carcinoma
BACKGROUND: Simultaneous inhibition of the vascular epithelial growth factor (VEGF) and
the mammalian target of rapamycin (mTOR) pathway may improve treatment response in …
the mammalian target of rapamycin (mTOR) pathway may improve treatment response in …
Clinical pharmacokinetics of ketorolac tromethamine
… Journal of Liquid Chromatography 12: 1835-1850, 1989b Jamali F, Brocks DR. Clinical
pharmacokinetics of ketoprofen and its enantiomers. Clinical Pharmacokinetics 19: 197217,1990 …
pharmacokinetics of ketoprofen and its enantiomers. Clinical Pharmacokinetics 19: 197217,1990 …
Metformin and exercise in type 2 diabetes: examining treatment modality interactions
… The authors would like to thank the study participants for their time and efforts and to thank
Dr. Jeffrey A. Johnson and Dr. Dean Eurich for their input; Dr. Ronald Dlin, Jason Howard, …
Dr. Jeffrey A. Johnson and Dr. Dean Eurich for their input; Dr. Ronald Dlin, Jason Howard, …