[PDF][PDF] Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments
…, R Fujii, S Watanabe, A Sai, S Fukuoka, E Sugiyama… - Cancer Cell, 2022 - cell.com
The balance of programmed death-1 (PD-1)-expressing CD8 + T cells and regulatory T (Treg)
cells in the tumor microenvironment (TME) determines the clinical efficacy of PD-1 …
cells in the tumor microenvironment (TME) determines the clinical efficacy of PD-1 …
Human placenta‐derived cells have mesenchymal stem/progenitor cell potential
Y Fukuchi, H Nakajima, D Sugiyama, I Hirose… - Stem …, 2004 - academic.oup.com
Mesenchymal stem/progenitor cells (MSCs) are widely distributed in a variety of tissues in
the adult human body (eg, bone marrow [BM], kidney, lung, and liver). These cells are also …
the adult human body (eg, bone marrow [BM], kidney, lung, and liver). These cells are also …
Meta-analysis: diagnostic accuracy of anti–cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis
K Nishimura, D Sugiyama, Y Kogata… - Annals of internal …, 2007 - acpjournals.org
Background: Rheumatoid factor (RF) and autoantibodies against cyclic citrullinated peptide (CCP)
are markers that might help physicians diagnose rheumatoid arthritis. Purpose: To …
are markers that might help physicians diagnose rheumatoid arthritis. Purpose: To …
Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies
D Sugiyama, K Nishimura, K Tamaki, G Tsuji… - Annals of the …, 2010 - ard.bmj.com
Objectives: To assess whether smoking is a risk factor for developing rheumatoid arthritis (RA).
Design: Meta-analysis. Method: Data sources were observational studies that examined …
Design: Meta-analysis. Method: Data sources were observational studies that examined …
Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers
…, H Nishikawa, H Wada, Y Nagano, D Sugiyama… - Nature medicine, 2016 - nature.com
CD4 + T cells that express the forkhead box P3 (FOXP3) transcription factor function as
regulatory T (T reg ) cells and hinder effective immune responses against cancer cells 1 , 2 , 3 . …
regulatory T (T reg ) cells and hinder effective immune responses against cancer cells 1 , 2 , 3 . …
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans
D Sugiyama, H Nishikawa, Y Maeda… - Proceedings of the …, 2013 - National Acad Sciences
CD4 + Treg cells expressing the transcription factor FOXP3 (forkhead box P3) are abundant
in tumor tissues and appear to hinder the induction of effective antitumor immunity. A …
in tumor tissues and appear to hinder the induction of effective antitumor immunity. A …
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
…, L Yuan, Q Jiang, B De Lafarge, D Sugiyama… - Nature, 2004 - nature.com
Blood vessels and nerves are complex, branched structures that share a high degree of
anatomical similarity. Guidance of vessels and nerves has to be exquisitely regulated to ensure …
anatomical similarity. Guidance of vessels and nerves has to be exquisitely regulated to ensure …
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells
…, S Savvi, A Saxena, A Schwegmann, D Sugiyama… - Science, 2015 - science.org
Although it is generally accepted that cellular differentiation requires changes to transcriptional
networks, dynamic regulation of promoters and enhancers at specific sets of genes has …
networks, dynamic regulation of promoters and enhancers at specific sets of genes has …
Outcomes in transcatheter aortic valve replacement for bicuspid versus tricuspid aortic valve stenosis
…, N Schofer, WKF Kong, E Tay, D Sugiyama… - Journal of the American …, 2017 - jacc.org
Background : Transcatheter aortic valve replacement (TAVR) is being increasingly performed
in patients with bicuspid aortic valve stenosis (AS). Objectives : This study sought to …
in patients with bicuspid aortic valve stenosis (AS). Objectives : This study sought to …
Fecal microbiota transplantation for patients with steroid-resistant acute graft-versus-host disease of the gut
…, I Mimura, H Morita, D Sugiyama… - Blood, The Journal …, 2016 - ashpublications.org
Increasing evidence indicates that the gut microbiota is closely associated with acute graft-versus-host
disease (aGVHD) in stem cell transplantation (SCT). Fecal microbiota …
disease (aGVHD) in stem cell transplantation (SCT). Fecal microbiota …