In cytosols from animal and plant cells, the abundant heat shock protein hsp90 is
associated with several proteins that act together to assemble steroid receptors into receptor·hsp90 …

It is established that agmatine, an endogenously formed decarboxylated arginine, is a weak
competitive inhibitor of neuronal nitric-oxide synthase (nNOS) with an apparent K i value of …

It is established that the multiprotein heat shock protein 90 (hsp90)-based chaperone
system acts on the ligand binding domain of the glucocorticoid receptor (GR) to form a GR·hsp90 …

Target selection for antibody–drug conjugates (ADC) frequently focuses on identifying
antigens with differential expression in tumor and normal tissue, to mitigate the risk of on-target …

It is established that suicide inactivation of neuronal nitric-oxide synthase (nNOS) with
guanidine compounds, or inhibition of the hsp90-based chaperone system with geldanamycin, …

… Demady are former employees of Knopp Neurosciences; Damon R. Demady has a continuing
equity interest in the company. Elizabeth A. Jonas is the recipient of a research grant from …

Guanabenz, a metabolism-based irreversible inactivator of neuronal nitric-oxide synthase (nNOS)
in vitro, causes the loss of immunodetectable nNOS in vivo. This process is selective …

It is established that aminoguanidine (AG) is a metabolism-based inactivator of the three major
isoforms of nitric-oxide synthase. AG is thought to be of potential use in diseases, such as …

It has been shown that administration of cigarette smoke to rats leads to loss of neuronal
nitric-oxide synthase (nNOS) activity and nNOS protein in penile tissue. The exact mechanism …

Although microtubule inhibitors (MTI) remain a therapeutically valuable payload option for
antibody drug conjugates (ADCs), some cancers do not respond to MTI-based ADCs. Efforts …