A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

…, MA Zanta, MD Mergny, D Scherman… - Proceedings of the …, 1995 - National Acad Sciences
Several polycations possessing substantial buffering capacity below physiological pH, such
as lipopolyamines and polyamidoamine polymers, are efficient transfection agents per se--ie…

The in vivo activation of persistent nanophosphors for optical imaging of vascularization, tumours and grafted cells

…, P Dorenbos, M Bessodes, D Gourier, D Scherman… - Nature materials, 2014 - nature.com
Optical imaging for biological applications requires more sensitive tools. Near-infrared
persistent luminescence nanoparticles enable highly sensitive in vivo optical detection and …

Protective role of interleukin-10 in atherosclerosis

…, C Fievet, B Staels, N Duverger, D Scherman… - Circulation …, 1999 - Am Heart Assoc
The potential role of anti-inflammatory cytokines in the modulation of the atherosclerotic
process remains unknown. Interleukin (IL)-10 has potent deactivating properties in …

High-efficiency gene transfer into skeletal muscle mediated by electric pulses

…, B Schwartz, D Scherman - Proceedings of the …, 1999 - National Acad Sciences
Gene delivery to skeletal muscle is a promising strategy for the treatment of muscle disorders
and for the systemic secretion of therapeutic proteins. However, present DNA delivery …

Nanoprobes with near-infrared persistent luminescence for in vivo imaging

…, D Gourier, M Bessodes, D Scherman - Proceedings of the …, 2007 - National Acad Sciences
Fluorescence is increasingly used for in vivo imaging and has provided remarkable results.
Yet this technique presents several limitations, especially due to tissue autofluorescence …

Controlling electron trap depth to enhance optical properties of persistent luminescence nanoparticles for in vivo imaging

…, D Gourier, C Richard, D Scherman - Journal of the …, 2011 - ACS Publications
Focusing on the use of nanophosphors for in vivo imaging and diagnosis applications, we
used thermally stimulated luminescence (TSL) measurements to study the influence of …

Synthesis, activity, and structure− activity relationship studies of novel cationic lipids for DNA transfer

…, P Wils, B Schwartz, D Scherman - Journal of medicinal …, 1998 - ACS Publications
We have designed and synthesized original cationic lipids for gene delivery. A synthetic
method on solid support allowed easy access to unsymmetrically monofunctionalized …

Striatal dopamine deficiency in Parkinson's disease: role of aging

D Scherman, C Desnos, F Darchen… - Annals of Neurology …, 1989 - Wiley Online Library
The striatal dopaminergic innervation was investigated postmortem in 49 control and 57
parkinsonian brains by assessing the binding of tritiated α‐dihydrotetrabenazine ([ 3 H]TBZOH), …

Plasmid DNA size does not affect the physicochemical properties of lipoplexes but modulates gene transfer efficiency

P Kreiss, P Mailhe, D Scherman, B Pitard… - Nucleic acids …, 1999 - academic.oup.com
Clinical applications of gene therapy mainly depend on the development of efficient gene
transfer vectors. Large DNA molecules can only be transfected into cells by using synthetic …

Storage of visible light for long-lasting phosphorescence in chromium-doped zinc gallate

…, T Maldiney, C Richard, D Scherman… - Chemistry of …, 2014 - ACS Publications
ZnGa 2 O 4 :Cr 3+ presents near-infrared long-lasting phosphorescence (LLP) suitable for
in vivo bioimaging. It is a bright LLP material showing a main thermally stimulated …