Unregulated or overexpressed matrix metalloproteinases (MMPs), including stromelysin,
collagenase, and gelatinase, have been implicated in several pathological conditions including …

ed nuclear Overhauser enhancement (NOE) techniques. In order to use this technique,
unambiguous assignments of the proton signals of the diene moiety and neighboring protons are …

Sequence-specific 1 H and 15 N resonance assignments have been made for all 145 non-prolyl
residues and for the flavin cofactor in oxidized Desulfovibrio vulgaris flavodoxin. …

Delavirdine mesylate (U-90152T) is a highly specific nonnucleoside HIV-1 reverse
transcriptase inhibitor currently under development for the treatment of AIDS. The metabolism of …

… McMilb %, Termnce A Scahill G*, and David A Klcosterman c a) Metabolic Diseases
Research, The Upjchn Co., Kalamazoo, MI 49001 b) Department of Chemistry, Columbia …

Efficient transport of intact drug (solute) across the intestinal epithelium is typically a requirement
for good oral activity. In general, the membrane permeability of a solute is a complex …

Delavirdine mesylate (U-90152T) is a highly specific nonnucleoside reverse transcriptase
inhibitor currently under development for the treatment of AIDS. The excretion, disposition, and …

Delavirdine mesylate (U-90152T) is a highly specific nonnucleoside HIV-1 reverse
transcriptase inhibitor currently under development for the treatment of AIDS. The excretion, …

Atevirdine mesylate (U-87201E) is a highly specific nonnucleoside inhibitor of human
immunodeficiency virus type 1 reverse transcriptase. The absorption, metabolism, and excretion of …

Mankind has come to a critical point with regard to bacterial infections. The emergence of new
strains of antibiotic-resistant bacteria makes the current battery of antibiotics unsuccessful …