[BOOK][B] Guide to cytochromes P450: structure and function

DFV Lewis - 1996 - taylorfrancis.com
This book covers the relevant aspects of cytochromes P450 for understanding their structure,
function and mechanisms of action, such as physicochemical characterization methods, …

57 varieties: the human cytochromes P450

DFV Lewis - Pharmacogenomics, 2004 - Taylor & Francis
The human cytochrome P450 (CYP) complement of heme-thiolate enzymes is reviewed. Of
the 57 individual P450s characterized in Homo sapiens thus far, it is apparent that …

[BOOK][B] Cytochromes

DFV Lewis - 2003 - books.google.com
David FV LewisDAVID FVLEWIS … In these elegant developments in molecular
toxicology, Dr David Lewis, the author of this erudite exposition The Cytochromes P450 …

Compound lipophilicity for substrate binding to human P450s in drug metabolism

DFV Lewis, MN Jacobs, M Dickins - Drug discovery today, 2004 - Elsevier
Compound lipophilicity is of key importance to P450 binding affinity and enzyme selectivity.
Here, lipophilicity is discussed with reference to the human drug-metabolizing P450 …

Human cytochromes P450 associated with the phase 1 metabolism of drugs and other xenobiotics: a compilation of substrates and inhibitors of the CYP1, CYP2 and …

DFV Lewis - Current medicinal chemistry, 2003 - ingentaconnect.com
This review represents a compilation of typical substrates and inhibitors for human cytochrome
P450 (CYP) enzymes that are involved in drug metabolism, specifically those from the …

On the recognition of mammalian microsomal cytochrome P450 substrates and their characteristics: towards the prediction of human p450 substrate specificity and …

DFV Lewis - Biochemical pharmacology, 2000 - Elsevier
The characteristics of mammalian microsomal P450 xenobiotic substrates are described,
particularly with reference to the major P450 isoforms associated with drug metabolism in …

[HTML][HTML] Interactions between redox partners in various cytochrome P450 systems: functional and structural aspects

DFV Lewis, P Hlavica - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2000 - Elsevier
The various types of redox partner interactions employed in cytochrome P450 systems are
described. The similarities and differences between the redox components in the major …

Contribution of CYP1A2 in the hepatic metabolism of melatonin: studies with isolated microsomal preparations and liver slices

…, E Hashemi, J Snelling, DFV Lewis… - Journal of pineal …, 2001 - Wiley Online Library
The objective of the present studies was to define the enzyme systems catalysing the 6‐hydroxylation
of melatonin, by monitoring the levels of 6‐sulphatoxymelatonin in rat hepatic …

Substrate SARs in human P450s

DFV Lewis, M Dickins - Drug discovery today, 2002 - Elsevier
Drug metabolism is now an integral part of the drug discovery process, and the cytochromes
P450 (CYPs) are the most important family of enzymes involved in human drug metabolism. …

Studies on the mechanism of coumarin-induced toxicity in rat hepatocytes: comparison with dihydrocoumarin and other coumarin metabolites

BG Lake, TJB Gray, JG Evans, DFV Lewis… - Toxicology and applied …, 1989 - Elsevier
Single doses of coumarin (125 mg/kg, ip) produced a depletion of hepatic nonprotein sulfhydryl
groups (mainly reduced glutathione; GSH) in young male Sprague-Dawley rats after 2 hr …