Drug interactions occur when the efficacy or toxicity of a medication is changed by administration
of another substance. Pharmacokinetic interactions often occur as a result of a change …

The novel finding that grapefruit juice can markedly augment oral drug bioavailability was
based on an unexpected observation from an interaction study between the dihydropyridine …

Objectives Our objective was to examine the effect of different fruits and their constituents on
P‐glycoprotein and organic anion transporting polypeptide (OATP) activities in vitro and on …

The increase in oral availability of felodipine and other commonly used medications when
taken with grapefruit juice has been assumed to be due to inhibition of CYP3A4, a cytochrome …

CME sequently, CYP3A4 activity in the small intestine is impaired until de novo synthesis
returns the enzyme to its previous level. This mechanism explains the important clinical effects …

A new type of interaction in which fruit juices diminish oral drug bioavailability through inhibition
of uptake transport is the focus of this review. The discovery was based on an opposite …

The acute hemodynamic and pharmacokinetic interactions between the vasodilating/diuretic
drugs ethanol and felodipine, a 1, 4-dihydropyridine calcium entry blocker, were assessed …

… David G. Bailey PhD… Bailey PhD …

This is a report of a symposium held at the March 1997 meeting of the American Society for
Pharmacology and Therapeutics in San Diego. Our understanding of the events that control …

Objectives The purpose of this study was to elucidate the potential clinical relevance and
mechanism(s) of action of 2 different volumes of grapefruit juice on the reduction of …