User profiles for David J. Greenblatt

David J Greenblatt

Tufts University
Verified email at Tufts.edu
Cited by 81552

Midazolam: pharmacology and uses.

JG Reves, RJ Fragen, HR Vinik, DJ Greenblatt - Anesthesiology, 1985 - europepmc.org
Midazolam is an imidazobenzodiazepine with unique properties when compared with other
benzodiazepines. It is water soluble in its acid formulation but is highly lipid soluble in vivo. …

Effect of obesity on the pharmacokinetics of drugs in humans

MJ Hanley, DR Abernethy, DJ Greenblatt - Clinical pharmacokinetics, 2010 - Springer
The prevalence of obesity has dramatically increased in recent years and now includes a
significant proportion of the world’s children, adolescents and adults. Obesity is linked to a …

Effect of age, gender, and obesity on midazolam kinetics.

DJ Greenblatt, DR Abernethy, A Locniskar… - …, 1984 - europepmc.org
The effects of age, sex, and obesity on the kinetics of single intravenous (iv) and oral doses
of midazolam were evaluated in healthy volunteers who received 2.5-5 mg of iv midazolam …

Effects of the antifungal agents on oxidative drug metabolism: clinical relevance

…, LL Von Moltke, DJ Greenblatt - Clinical …, 2000 - Springer
This article reviews the metabolic pharmacokinetic drug-drug interactions with the systemic
antifungal agents: the azoles ketoconazole, miconazole, itraconazole and fluconazole, the …

Drug disposition in old age

DJ Greenblatt, EM Sellers… - New England Journal of …, 1982 - Mass Medical Soc
THE appropriate and rational use of drugs by the elderly is a matter of growing medical and
social concern. Life expectancy in the Western world currently stands at 69 years for men …

Benzodiazepine overdosage: plasma concentrations and clinical outcome

M Divoll, DJ Greenblatt, Y Lacasse, RI Shader - Psychopharmacology, 1981 - Springer
Plasma concentrations and their relation to clinical outcome were evaluated in 21 patients
who reached emergency treatment facilities following acute overdosage with benzodiazepine …

Interaction of warfarin with drugs, natural substances, and foods

DJ Greenblatt, LL von Moltke - The Journal of Clinical …, 2005 - Wiley Online Library
Variability in the anticoagulant response to warfarin is an ongoing clinical dilemma. Fluctuations
in dietary vitamin K are an important source of variance, and the need for constancy in …

Use of benzodiazepines in anxiety disorders

RI Shader, DJ Greenblatt - New England Journal of Medicine, 1993 - Mass Medical Soc
Beginning with chlordiazepoxide in 1960, benzodiazepines have been used extensively for
the treatment of anxiety and related disorders. Eight benzodiazepine derivatives have been …

Dose‐dependent pharmacokinetics and psychomotor effects of caffeine in humans

GB Kaplan, DJ Greenblatt… - The Journal of …, 1997 - Wiley Online Library
Twelve healthy volunteers received oral placebo, 250 mg of caffeine, and 500 mg of
caffeine in a randomized, double‐blind, single‐dose crossover study. Caffeine kinetics were …

Propranolol interactions with diazepam, lorazepam, and alprazolam

HR Ochs, DJ Greenblatt… - Clinical Pharmacology & …, 1984 - Wiley Online Library
J Pharmacol Exp Ther 205:516-524, 1978. 13. Ochs HR, Carstens G, Greenblatt DJ: Reduction
in lidocaine … N Engl J Med 303:373-377, 1980. 14. Ochs HR, Carstens G, Roberts GM, …