• In 1988, the MacArthur Foundation Research Network on the Psychobiology of Depression
convened a task force to examine the ways in which change points in the course of …

Despite the prevalence of sleep complaints among psychiatric patients, few questionnaires
have been specifically designed to measure sleep quality in clinical populations. The …

Objective: This report describes the participants and compares the acute and longer-term
treatment outcomes associated with each of four successive steps in the Sequenced Treatment …

OBJECTIVE: The authors developed a methodological basis for investigating how risk
factors work together. Better methods are needed for understanding the etiology of disorders, …

Terms such as risk, risk factors, and especially the term cause are inconsistently and
imprecisely used, fostering scientific miscommunication and misleading research and policy. …

• We conducted a randomized 3-year maintenance trial in 128 patients with recurrent
depression who had responded to combined short-term and continuation treatment with …

Objective The DSM-5 Field Trials were designed to obtain precise (standard error <0.1)
estimates of the intraclass kappa as a measure of the degree to which two clinicians could …

Data from rodent studies indicate that cumulative stress exposure may accelerate senescence
and offer a theory to explain differences in the rate of aging. Cumulative exposure to …

Subjective sleep quality deteriorates with aging, but the extent to which this is a product of
age itself, as opposed to the medical or psychiatric problems associated with aging, has not …

STAR*D is a multisite, prospective, randomized, multistep clinical trial of outpatients with
nonpsychotic major depressive disorder. The study compares various treatment options for …