Pregnancy is associated with numerous physiological changes that influence absorption,
distribution, metabolism and excretion. Moreover, the magnitude of these effects changes as …

Over the past three decades, the Isolated Perfused Rat Kidney (IPK) has been used to study
numerous aspects of renal drug disposition. Among the available ex-vivo methods to study …

This title demonstrates how advanced formulation designs and delivery technologies can be
used to improve drug efficacy and treatment outcomes in particular therapeutic categories …

ON 01210.Na (Ex-RAD), a chlorobenzylsulfone derivative was investigated for its pharmacologic
and radioprotective properties when administered via oral and subcutaneous (SC) …

Publisher Summary This chapter offers a comprehensive summary of drug excretion,
presenting an overview of membrane transporters in terms of classification, nomenclature, and …

Clinical studies in preterm neonates are rarely performed due to ethical concerns and difficulties
associated with trials and recruitment. Consequently, dose selection in this population …

As editors of the second edition of Preclinical Drug Development, we are pleased to present
this updated text on the science of safely moving therapeutic candidates into, and through, …

Purpose ON 01910.Na is a novel targeted anti-cancer agent under clinical investigation in
Phase I and II trials. The purpose of this research was to evaluate the pharmacokinetic profile …

Aristolochic acids are natural nitro-compounds found globally in the plant genus Aristolochia
that have been implicated in the severe illness in humans termed aristolochic acid …

Background Although nucleoside reverse transcriptase inhibitors have been associated
with lactic acidosis, lamivudine (3TC) has not been reported to have an increased risk with …