Human small intestine epithelial cells (enterocytes) provide the first site for cytochrome P-450
(CYP)-catalyzed metabolism of orally ingested xenobiotics. The CYP composition of …

Human small intestine epithelial cells (enterocytes) provide the first site for cytochrome P450
(CYP)-catalyzed metabolism of orally ingested xenobiotics. CYP3A4 is the major form of …

The composition and inducibility of cytochrome P450 (P450) in rat small intestinal epithelial
cells were investigated with the use of RNA-polymerase chain reaction and immunoblot …

Retinoic acids have important pleiotropic biological effects and thus the potential for human
cytochrome P-450s (CYPs) to mediate retinoic acid synthesis was investigated. We …

Small intestinal cytochromes P450 (P450s) provide potential first-pass metabolism of ingested
xenobiotics. To investigate this system, this study addresses the procedure for elution of …

The predominant inducible cytochrome P450 (CYP) in rat small intestine is CYP1A1, which,
when induced to elevated levels by xenobiotics or dietary constituents, has the potential to …

A facile method was established to measure heterocyclic aromatic amines (HAAs) accumulated
in human hair and rodent fur. The samples were digested by base hydrolysis, and the …

To determine the in vivo function of intestinal cytochrome P450 (P450) enzymes, we have
generated an intestinal epithelium (IE)-specific P450 reductase gene (Cpr) knockout mouse …

To determine the effect of intestinal cytochrome P450 (P450) enzymes on the bioavailability
of oral drugs, we have examined the metabolism of nifedipine, an antihypertensive drug and …

This exploratory study examined whether outcomes of care for HIV‐infected patients are
related to whether the patient's primary provider is a physician (MD) or a nurse practitioner (NP). …