Design, synthesis and selection of DNA-encoded small-molecule libraries

…, SL Belyanskaya, DR Benjamin… - Nature chemical …, 2009 - nature.com
Biochemical combinatorial techniques such as phage display, RNA display and oligonucleotide
aptamers have proven to be reliable methods for generation of ligands to protein targets…

Contribution of linker stability to the activities of anticancer immunoconjugates

SC Alley, DR Benjamin, SC Jeffrey… - Bioconjugate …, 2008 - ACS Publications
The linker component of antibody−drug conjugates (ADC) is a key feature in developing
optimized therapeutic agents that are highly active at well tolerated doses. For maximal …

Intracellular activation of SGN-35, a potent anti-CD30 antibody-drug conjugate

…, X Zhang, RJ Sanderson, DR Benjamin… - Clinical Cancer …, 2010 - AACR
Purpose: SGN-35 is an antibody-drug conjugate (ADC) containing the potent antimitotic drug,
monomethylauristatin E (MMAE), linked to the anti-CD30 monoclonal antibody, cAC10. As …

SGN-CD33A: a novel CD33-targeting antibody–drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML

…, ID Bernstein, PD Senter, DR Benjamin… - Blood, The Journal …, 2013 - ashpublications.org
Outcomes in acute myeloid leukemia (AML) remain unsatisfactory, and novel treatments are
urgently needed. One strategy explores antibodies and their drug conjugates, particularly …

Intracellular released payload influences potency and bystander-killing effects of antibody-drug conjugates in preclinical models

…, ND Nicholas, NM Okeley, RP Lyon, DR Benjamin… - Cancer research, 2016 - AACR
Antibody-drug conjugates (ADC) comprise targeting antibodies armed with potent small-molecule
payloads. ADCs demonstrate specific cell killing in clinic, but the basis of their …

Development of orally active inhibitors of protein and cellular fucosylation

…, W Zeng, X Zhang, DR Benjamin… - Proceedings of the …, 2013 - National Acad Sciences
The key role played by fucose in glycoprotein and cellular function has prompted significant
research toward identifying recombinant and biochemical strategies for blocking its …

Detection and selective dissociation of intact ribosomes in a mass spectrometer

AA Rostom, P Fucini, DR Benjamin… - Proceedings of the …, 2000 - National Acad Sciences
Intact Escherichia coli ribosomes have been projected into the gas phase of a mass
spectrometer by means of nanoflow electrospray techniques. Species with mass/charge ratios in …

SGN–LIV1A: A novel antibody–drug conjugate targeting LIV-1 for the treatment of metastatic breast cancer

…, HA Van Epps, N Whiting, DR Benjamin - Molecular cancer …, 2014 - AACR
In this article, we describe a novel antibody–drug conjugate (ADC; SGN–LIV1A), targeting
the zinc transporter LIV-1 (SLC39A6) for the treatment of metastatic breast cancer. LIV-1 was …

Engel versus Baumol: Accounting for structural change using two centuries of US data

BN Dennis, TB İşcan - Explorations in Economic history, 2009 - Elsevier
In the last two centuries, the reallocation of labor out of agriculture has been a dominant
feature of structural change and economic growth in the United States. This paper uses an …

The pharmacologic basis for antibody-auristatin conjugate activity

…, M Anderson, CL Law, PD Senter, DR Benjamin - … of Pharmacology and …, 2009 - ASPET
Antibody-drug conjugates (ADCs) made with auristatin antimitotic agents have shown
significant preclinical and clinical oncology activity. SGN-75 is composed of the anti-CD70 …