Inhibition of intestinal cholesterol absorption by ezetimibe in humans
T Sudhop, D Lütjohann, A Kodal, M Igel, DL Tribble… - Circulation, 2002 - Am Heart Assoc
Background— Ezetimibe has been shown to inhibit cholesterol absorption in animal models,
but studies on cholesterol absorption in humans have not been performed thus far. …
but studies on cholesterol absorption in humans have not been performed thus far. …
[HTML][HTML] Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation
I Björkhem, D Lütjohann, U Diczfalusy, L Ståhle… - Journal of lipid …, 1998 - ASBMB
We have previously demonstrated that the brain contains about 80% of the 24S-hydroxycholesterol
in the human body and that there is a net flux of this steroid from the brain into the …
in the human body and that there is a net flux of this steroid from the brain into the …
[HTML][HTML] Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease
Objective This EAS Consensus Panel critically appraised evidence relevant to the benefit to
risk relationship of functional foods with added plant sterols and/or plant stanols, as …
risk relationship of functional foods with added plant sterols and/or plant stanols, as …
Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: a 26‐week randomized, placebo‐controlled, double‐blind trial
M Simons, F Schwärzler, D Lütjohann… - Annals of …, 2002 - Wiley Online Library
In a randomized, placebo‐controlled, double‐blind study, we investigated whether statins
alter cholesterol metabolites and reduce Aβ levels in the cerebrospinal fluid of 44 patients with …
alter cholesterol metabolites and reduce Aβ levels in the cerebrospinal fluid of 44 patients with …
[PDF][PDF] Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis
…, V Bieghs, MJ Gijbels, H Duimel, D Lütjohann… - …, 2008 - Wiley Online Library
Nonalcoholic steatohepatitis (NASH) involves liver lipid accumulation (steatosis) combined
with hepatic inflammation. The transition towards hepatic inflammation represents a key step …
with hepatic inflammation. The transition towards hepatic inflammation represents a key step …
[HTML][HTML] Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients
D Lütjohann, A Papassotiropoulos, I Björkhem… - Journal of lipid …, 2000 - ASBMB
Alzheimer's disease (AD) is characterized by the presence of senile plaques, neurofibrillary
tangles, and neuronal cell loss associated with membrane cholesterol release. 24S-…
tangles, and neuronal cell loss associated with membrane cholesterol release. 24S-…
High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3
…, P Knolle, M Kneilling, M Röcken, D Lütjohann… - Nature …, 2014 - nature.com
High-density lipoprotein (HDL) mediates reverse cholesterol transport and is known to be
protective against atherosclerosis. In addition, HDL has potent anti-inflammatory properties …
protective against atherosclerosis. In addition, HDL has potent anti-inflammatory properties …
Defective cholesterol clearance limits remyelination in the aged central nervous system
…, M Mitkovski, G Trendelenburg, D Lütjohann… - Science, 2018 - science.org
Age-associated decline in regeneration capacity limits the restoration of nervous system
functionality after injury. In a model for demyelination, we found that old mice fail to resolve the …
functionality after injury. In a model for demyelination, we found that old mice fail to resolve the …
High‐dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial
…, K von Bergmann, D Lütjohann… - Clinical …, 2005 - Wiley Online Library
Background Myopathy, probably caused by 3‐hydroxy‐3‐methylglutaryl‐coenzyme A
reductase inhibition in skeletal muscle, rarely occurs in patients taking statins. This study was …
reductase inhibition in skeletal muscle, rarely occurs in patients taking statins. This study was …
[HTML][HTML] Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease
M Heverin, N Bogdanovic, D Lütjohann, T Bayer… - Journal of lipid …, 2004 - ASBMB
24S-hydroxycholesterol is a side-chain oxidized oxysterol formed in the brain that is continuously
crossing the blood-brain barrier to reach the circulation. There may be an opposite flux …
crossing the blood-brain barrier to reach the circulation. There may be an opposite flux …