Inhibition of intestinal cholesterol absorption by ezetimibe in humans

T Sudhop, D Lütjohann, A Kodal, M Igel, DL Tribble… - Circulation, 2002 - Am Heart Assoc
Background— Ezetimibe has been shown to inhibit cholesterol absorption in animal models,
but studies on cholesterol absorption in humans have not been performed thus far. …

[HTML][HTML] Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

I Björkhem, D Lütjohann, U Diczfalusy, L Ståhle… - Journal of lipid …, 1998 - ASBMB
We have previously demonstrated that the brain contains about 80% of the 24S-hydroxycholesterol
in the human body and that there is a net flux of this steroid from the brain into the …

[HTML][HTML] Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease

…, L Ellegård, W Jessup, PJ Jones, D Lütjohann… - Atherosclerosis, 2014 - Elsevier
Objective This EAS Consensus Panel critically appraised evidence relevant to the benefit to
risk relationship of functional foods with added plant sterols and/or plant stanols, as …

Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: a 26‐week randomized, placebo‐controlled, double‐blind trial

M Simons, F Schwärzler, D Lütjohann… - Annals of …, 2002 - Wiley Online Library
In a randomized, placebo‐controlled, double‐blind study, we investigated whether statins
alter cholesterol metabolites and reduce Aβ levels in the cerebrospinal fluid of 44 patients with …

[PDF][PDF] Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis

…, V Bieghs, MJ Gijbels, H Duimel, D Lütjohann… - …, 2008 - Wiley Online Library
Nonalcoholic steatohepatitis (NASH) involves liver lipid accumulation (steatosis) combined
with hepatic inflammation. The transition towards hepatic inflammation represents a key step …

[HTML][HTML] Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients

D Lütjohann, A Papassotiropoulos, I Björkhem… - Journal of lipid …, 2000 - ASBMB
Alzheimer's disease (AD) is characterized by the presence of senile plaques, neurofibrillary
tangles, and neuronal cell loss associated with membrane cholesterol release. 24S-…

High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3

…, P Knolle, M Kneilling, M Röcken, D Lütjohann… - Nature …, 2014 - nature.com
High-density lipoprotein (HDL) mediates reverse cholesterol transport and is known to be
protective against atherosclerosis. In addition, HDL has potent anti-inflammatory properties …

Defective cholesterol clearance limits remyelination in the aged central nervous system

…, M Mitkovski, G Trendelenburg, D Lütjohann… - Science, 2018 - science.org
Age-associated decline in regeneration capacity limits the restoration of nervous system
functionality after injury. In a model for demyelination, we found that old mice fail to resolve the …

High‐dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial

…, K von Bergmann, D Lütjohann… - Clinical …, 2005 - Wiley Online Library
Background Myopathy, probably caused by 3‐hydroxy‐3‐methylglutaryl‐coenzyme A
reductase inhibition in skeletal muscle, rarely occurs in patients taking statins. This study was …

[HTML][HTML] Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

M Heverin, N Bogdanovic, D Lütjohann, T Bayer… - Journal of lipid …, 2004 - ASBMB
24S-hydroxycholesterol is a side-chain oxidized oxysterol formed in the brain that is continuously
crossing the blood-brain barrier to reach the circulation. There may be an opposite flux …