The clinical pharmacokinetic behavior of paclitaxel (Taxol) is distinctly nonlinear, with
disproportional increases in systemic exposure with an increase in dose. We have recently shown …

It has been hypothesized that the paclitaxel vehicle Cremophor EL (CrEL) is responsible for
nonlinear drug disposition by micellar entrapment. To gain further insight into the role of …

Most radiolabeled biological samples require extensive sample preparation to reduce quenching
interference before quantification of radioactivity is possible. Clearly, a more rapid and …

Elektronica zijn steeds belangrijker geworden in ons dagelijks leven. Met name mobiele
telefoons, maar ook computers zijn niet meer weg te denken. Maar zijn ze belangrijk genoeg …

Aan de vereerende uitnoodiging van de Rotterdamsche Commissie voor het onderzoek van
de verschijnselen op den Oceaan, om eene spreekbeurt te vervullen op hare jaarlijksche …

Recently, cereblon (CRBN) expression was found to be essential for the activity of thalidomide
and lenalidomide. In the present study, we investigated whether the clinical efficacy of …

Objective Our objectives were to study the extent of docetaxel binding to plasma in the
presence and absence of its excipient, polysorbate 80 (Tween 80; Imperial Chemical Industries …

Abstract 3973 Introduction: Cereblon (CRBN) expression has been described to be essential
for the activity of Thalidomide and Lenalidomide. This suggests that presence and possibly …

Background: Irinotecan is a topoisomerase I inhibitor that has been approved for use as a
first- and second-line treatment for colorectal cancer. The response to irinotecan is variable, …