Direct injection of samples on high-resolving mass spectrometers is an effective way to maximize
analytical throughput and yet allow analyte discrimination in complex samples by mass-…

The production of fuel ethanol from low‐cost lignocellulosic biomass currently suffers from
several limitations. One of them is the presence of inhibitors in lignocellulosic hydrolysates …

Biofuels derived from lignocellulosic biomass hold promises for a sustainable fuel economy,
but several problems hamper their economical feasibility. One important problem is the …

Background The concerted effects of changes in gene expression due to changes in the
environment are ultimately reflected in the metabolome. Dynamics of metabolite concentrations …

6β-Hydroxycortisol (6β-OHF) is a substrate of the organic anion transporter 3 (OAT3) and
the multidrug and toxin extrusion proteins MATE1 and MATE-2K in the corresponding cDNA-…

Mutations in glucocerebrosidase cause the lysosomal storage disorder Gaucher’s disease
and are the most common risk factor for Parkinson’s disease. Therapies to restore the enzyme…

Economically feasible bioethanol process from lignocellulose requires efficient fermentation
by yeast of all sugars present in the hydrolysate. However, when exposed to lignocellulosic …

Monoacylglycerol lipase (MAGL) is one of the key enzymes in the endocannabinoid system.
Inhibition of MAGL has been proposed as an attractive approach for the treatment of various …

New potent, selective monoacylglycerol lipase (MAGL) inhibitors based on the azetidin-2-one
scaffold ((±)-5a–v, (±)-6a–j, and (±)-7a–d) were developed as irreversible ligands, as …

Alzheimer’s Disease (AD) is the most widespread form of dementia, with one of the pathological
hallmarks being the formation of neurofibrillary tangles (NFTs). These tangles consist of …