High-throughput, accurate mass metabolome profiling of cellular extracts by flow injection–time-of-flight mass spectrometry
Direct injection of samples on high-resolving mass spectrometers is an effective way to maximize
analytical throughput and yet allow analyte discrimination in complex samples by mass-…
analytical throughput and yet allow analyte discrimination in complex samples by mass-…
Identification of furfural as a key toxin in lignocellulosic hydrolysates and evolution of a tolerant yeast strain
D Heer, U Sauer - Microbial biotechnology, 2008 - Wiley Online Library
The production of fuel ethanol from low‐cost lignocellulosic biomass currently suffers from
several limitations. One of them is the presence of inhibitors in lignocellulosic hydrolysates …
several limitations. One of them is the presence of inhibitors in lignocellulosic hydrolysates …
Resistance of Saccharomyces cerevisiae to High Concentrations of Furfural Is Based on NADPH-Dependent Reduction by at Least Two Oxireductases
D Heer, D Heine, U Sauer - Applied and environmental …, 2009 - Am Soc Microbiol
Biofuels derived from lignocellulosic biomass hold promises for a sustainable fuel economy,
but several problems hamper their economical feasibility. One important problem is the …
but several problems hamper their economical feasibility. One important problem is the …
[HTML][HTML] Dynamic metabolomics differentiates between carbon and energy starvation in recombinant Saccharomyces cerevisiae fermenting xylose
B Bergdahl, D Heer, U Sauer, B Hahn-Hägerdal… - Biotechnology for …, 2012 - Springer
Background The concerted effects of changes in gene expression due to changes in the
environment are ultimately reflected in the metabolome. Dynamics of metabolite concentrations …
environment are ultimately reflected in the metabolome. Dynamics of metabolite concentrations …
6β-hydroxycortisol is an endogenous probe for evaluation of drug–drug interactions involving a multispecific renal organic anion transporter, OAT3/SLC22A8, in …
Y Imamura, Y Tsuruya, K Damme, D Heer… - Drug Metabolism and …, 2014 - ASPET
6β-Hydroxycortisol (6β-OHF) is a substrate of the organic anion transporter 3 (OAT3) and
the multidrug and toxin extrusion proteins MATE1 and MATE-2K in the corresponding cDNA-…
the multidrug and toxin extrusion proteins MATE1 and MATE-2K in the corresponding cDNA-…
[HTML][HTML] Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct
…, S von der Mark, R Thoma, A Rufer, D Heer… - Nature …, 2023 - nature.com
Mutations in glucocerebrosidase cause the lysosomal storage disorder Gaucher’s disease
and are the most common risk factor for Parkinson’s disease. Therapies to restore the enzyme…
and are the most common risk factor for Parkinson’s disease. Therapies to restore the enzyme…
[HTML][HTML] Physiological and Molecular Characterization of Yeast Cultures Pre-Adapted for Fermentation of Lignocellulosic Hydrolysate
Economically feasible bioethanol process from lignocellulose requires efficient fermentation
by yeast of all sugars present in the hydrolysate. However, when exposed to lignocellulosic …
by yeast of all sugars present in the hydrolysate. However, when exposed to lignocellulosic …
Development of high brain-penetrant and reversible monoacylglycerol lipase PET tracers for neuroimaging
…, U Grether, J Benz, L Leibrock, D Heer… - Journal of Medicinal …, 2022 - ACS Publications
Monoacylglycerol lipase (MAGL) is one of the key enzymes in the endocannabinoid system.
Inhibition of MAGL has been proposed as an attractive approach for the treatment of various …
Inhibition of MAGL has been proposed as an attractive approach for the treatment of various …
Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization
…, A Ramunno, AF Stevens, D Heer… - Journal of Medicinal …, 2024 - ACS Publications
New potent, selective monoacylglycerol lipase (MAGL) inhibitors based on the azetidin-2-one
scaffold ((±)-5a–v, (±)-6a–j, and (±)-7a–d) were developed as irreversible ligands, as …
scaffold ((±)-5a–v, (±)-6a–j, and (±)-7a–d) were developed as irreversible ligands, as …
Discovery of Orally Available and Brain Penetrant AEP Inhibitors
…, F Morandi, S Gutbier, A Schuler, D Heer… - Journal of Medicinal …, 2023 - ACS Publications
Alzheimer’s Disease (AD) is the most widespread form of dementia, with one of the pathological
hallmarks being the formation of neurofibrillary tangles (NFTs). These tangles consist of …
hallmarks being the formation of neurofibrillary tangles (NFTs). These tangles consist of …