Interpreting the toxicologic significance of alterations in anogenital distance: potential for confounding effects of progeny body weights
RH Gallavan Jr, JF Holson, DG Stump, JF Knapp… - Reproductive …, 1999 - Elsevier
Anogenital distance (AGD) is an endpoint that was recently added to the US EPA testing
guidelines for reproductive toxicity studies. This endpoint is sensitive to hormonal effects of test …
guidelines for reproductive toxicity studies. This endpoint is sensitive to hormonal effects of test …
Gestational and lactational exposure to potassium perfluorooctanesulfonate (K+ PFOS) in rats: developmental neurotoxicity
…, DJ Ehresman, SC Chang, GA Parker, DG Stump - Reproductive …, 2009 - Elsevier
Perfluorooctanesulfonate (PFOS), a persistent and bioaccumulative compound, is widely
distributed in humans and wildlife. Exposure of the human fetus and neonate to PFOS can …
distributed in humans and wildlife. Exposure of the human fetus and neonate to PFOS can …
Postnatal development of the testis in the rat: morphologic study and correlation of morphology to neuroendocrine parameters
…, EPCT de Rijk, ML Simons, DG Stump… - Toxicologic …, 2015 - journals.sagepub.com
Histopathologic examination of the testis from juvenile rats is often necessary to characterize
the safety of new drugs for pediatric use and is a required end point in male pubertal …
the safety of new drugs for pediatric use and is a required end point in male pubertal …
Gestational and lactational exposure to potassium perfluorooctanesulfonate (K+ PFOS) in rats: toxicokinetics, thyroid hormone status, and related gene expression
…, JA Bjork, KB Wallace, GA Parker, DG Stump… - Reproductive …, 2009 - Elsevier
Perfluorooctanesulfonate (PFOS), a persistent and accumulative compound, is widely
distributed in humans and wildlife. Human exposure can occur early in development, as …
distributed in humans and wildlife. Human exposure can occur early in development, as …
Postnatal ovary development in the rat: morphologic study and correlation of morphology to neuroendocrine parameters
CA Picut, D Dixon, ML Simons, DG Stump… - Toxicologic …, 2015 - journals.sagepub.com
Histopathologic examination of the immature ovary is a required end point on juvenile
toxicity studies and female pubertal and thyroid function assays. To aid in this evaluation and …
toxicity studies and female pubertal and thyroid function assays. To aid in this evaluation and …
Developmental neurotoxicity study of dietary bisphenol A in Sprague-Dawley rats
DG Stump, MJ Beck, A Radovsky… - Toxicological …, 2010 - academic.oup.com
This study was conducted to determine the potential of bisphenol A (BPA) to induce functional
and/or morphological effects to the nervous system of F 1 offspring from dietary exposure …
and/or morphological effects to the nervous system of F 1 offspring from dietary exposure …
A two-generation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in rats exposed by whole-body vapor inhalation
WH Siddiqui, DG Stump, KP Plotzke, JF Holson… - Reproductive …, 2007 - Elsevier
This study evaluated the potential toxicity of whole-body vapor inhalation of
octamethylcyclotetrasiloxane (D 4 ) on reproductive capabilities in exposed F 0 and F 1 parental …
octamethylcyclotetrasiloxane (D 4 ) on reproductive capabilities in exposed F 0 and F 1 parental …
An inhalation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in female rats using multiple and single day exposure regimens
RG Meeks, DG Stump, WH Siddiqui, JF Holson… - Reproductive …, 2007 - Elsevier
Octamethylcyclotetrasiloxane (D 4 ) has been shown to have effects on the female rat
reproductive cycle. This study evaluated the phase of the female rat reproductive cycle affected by …
reproductive cycle. This study evaluated the phase of the female rat reproductive cycle affected by …
Juvenile animal toxicity study designs to support pediatric drug development
…, AM Hoberman, Y Ooshima, DG Stump… - … Research Part B …, 2009 - Wiley Online Library
The objective of juvenile animal toxicity studies of pharmaceuticals is to obtain safety data,
including information on the potential for adverse effects on postnatal growth and …
including information on the potential for adverse effects on postnatal growth and …
A retinoic acid response element from the rat CRBPI promoter is activated by an RARRXR heterodimer
M Husmann, B Hoffmann, DG Stump, F Chytil… - Biochemical and …, 1992 - Elsevier
The expression of the rat cellular retinol binding protein I (rCRBPI) can be upregulated in vivo
by retinoic acid (RA). Here we have analyzed the rCRBPI promoter region and compared it …
by retinoic acid (RA). Here we have analyzed the rCRBPI promoter region and compared it …