Purpose Panax ginseng and its extracts have long been used for medical purposes; there is
increasing interest in developing ginseng products as cancer preventive or therapeutic …

The oncoprotein MDM2, a major ubiquitin E3 ligase of tumor suppressor p53, has been
suggested as a novel target for human cancer therapy based on its p53-dependent and p53-…

In eukaryotes, end-binding (EB) proteins serve as a hub for orchestrating microtubule dynamics
and are essential for cellular dynamics and organelle movements. EB proteins modulate …

BACKGROUND Ginseng and its components exert various biological effects, including
antioxidant, anti‐carcinogenic, anti‐mutagenic, and anti‐tumor activity, and recent research has …

Although genistein has chemopreventive effects in several human malignancies, including
cancers of the breast, colon, and prostate, the mechanisms of action are not fully understood. …

Faithful segregation of chromosomes in mammalian cells requires bi-orientation of sister
chromatids, which relies on the sensing of correct attachments between spindle microtubules …

Dexamethasone (DEX) is mainly used as an anti-emetic agent in cancer therapy. We have
recently demonstrated that DEX pretreatment increases the antitumor activity of the cancer …

Liquid–liquid phase separation (LLPS) of biomolecules drives the formation of subcellular
compartments with distinct physicochemical properties. These compartments, free of lipid …

The spindle assembly checkpoint (SAC) is a conserved signaling pathway that monitors faithful
chromosome segregation during mitosis. As a core component of SAC, the evolutionarily …

Cyclophosphamide is converted by enzymes of mouse liver into two metabolites. Production
of the first (aldophosphamide), which is uncharged, requires TPNH, is inhibited by CO, and …