Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

S Tsukada, DC Saffran, DJ Rawlings, O Parolini… - Cell, 1993 - cell.com
We describe a novel cytoplasmic tyrosine kinase, termed BPK (B cell progenitor kinase), which
is expressed in all stages of the B lineage and in myeloid cells. BPK has classic SH1, SH2…

Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice

DJ Rawlings, DC Saffran, S Tsukada, DA Largaespada… - Science, 1993 - science.org
The cytoplasmic tyrosine kinase, Bruton's tyrosine kinase (Btk, formerly bpk or atk), is crucial
for B cell development. Loss of kinase activity results in the human immunodeficiency, X-…

STEAP: a prostate-specific cell-surface antigen highly expressed in human prostate tumors

…, A Jakobovits, DC Saffran… - Proceedings of the …, 1999 - National Acad Sciences
In search of novel genes expressed in metastatic prostate cancer, we subtracted cDNA
isolated from benign prostatic hypertrophic tissue from cDNA isolated from a prostate cancer …

Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia

…, I Vivanco, RS Hubert, J Kuo, E Chen, DC Saffran… - Cancer research, 2001 - AACR
We identified TMPRSS2 as a gene that is down-regulated in androgen-independent
prostate cancer xenograft tissue derived from a bone metastasis. Using specific monoclonal …

Anti-PSCA mAbs inhibit tumor growth and metastasis formation and prolong the survival of mice bearing human prostate cancer xenografts

DC Saffran, AB Raitano, RS Hubert… - Proceedings of the …, 2001 - National Acad Sciences
Prostate stem-cell antigen (PSCA) is a cell-surface antigen expressed in normal prostate
and overexpressed in prostate cancer tissues. PSCA expression is detected in over 80% of …

Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

A Goga, J McLaughlin, DEH Afar, DC Saffran, ON Witte - Cell, 1995 - Elsevier
Biological function of the BCR-ABL oncogene is dependent on its activated tyrosine kinase.
Mutations that inactivate the SRC homology 2 (SH2) domain, the GRB2-binding site in BCR, …

[PDF][PDF] Modulating androgen receptor-driven transcription in prostate cancer with selective CDK9 inhibitors

…, J Vacca, CM Wilfong, BW Trotter, DC Saffran… - Cell chemical …, 2021 - cell.com
Castration-resistant prostate cancers (CRPCs) lose sensitivity to androgen-deprivation
therapies but frequently remain dependent on oncogenic transcription driven by the androgen …

[HTML][HTML] A point mutation in the SH2 domain of Bruton's tyrosine kinase in atypical X-linked agammaglobulinemia

DC Saffran, O Parolini… - … England Journal of …, 1994 - Mass Medical Soc
X-Linked Agammaglobulinemia is the prototypical humoral immunodeficiency first described
by Bruton in 1952 1 . It is characterized by a paucity of circulating B cells and a drastic …

The discovery and optimization of a novel class of potent, selective, and orally bioavailable anaplastic lymphoma kinase (ALK) inhibitors with potential utility for the …

…, PS Andrews, VL Yu, DC Saffran… - Journal of medicinal …, 2012 - ACS Publications
A class of 2-acyliminobenzimidazoles has been developed as potent and selective
inhibitors of anaplastic lymphoma kinase (ALK). Structure based design facilitated the rapid …

Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers

…, C Lee, H Li, M Zhou, DC Saffran… - Journal of Medicinal …, 2023 - ACS Publications
Transcriptional deregulation is a hallmark of many cancers and is exemplified by genomic
amplifications of the MYC family of oncogenes, which occur in at least 20% of all solid tumors …