A diverse group of chemicals cause a male rat-specific nephrotoxicity in which α2u-globulin
accumulates in renal lysosomes. It has been suggested that these chemicals bind to the …

The rate-limiting step in chemically induced, male rat-specific hyaline droplet nephropathy
is the reversible binding of a xenobiotic to α2u-globulin. In this study, equilibrium saturation …

Coumarin, a widely used fragrance ingredient, is a rat liver and mouse lung toxicant. Species
differences in toxicity are metabolism-dependent, with injury resulting from the cytochrome …

d-Limonene is a naturally occurring monoterpene, which when dosed orally, causes a male
ratspecific nephrotoxicity manifested acutely as the exacerbation of protein droplets in …

… Douglas Caudill , Douglas Caudill … Born, Douglas Caudill, Bill J. Smith, Lois D. Lehman-McKeeman,
In Vitro Kinetics of Coumarin 3,4-Epoxidation: Application to Species Differences in …

It is well-established that binding of a chemical to α 2u -globulin is the rate-limiting step in
the development of male rat-specific hyaline droplet nephropathy. Mice synthesize mouse …

Coumarin is a known hepatotoxicant in laboratory animals, particularly rats. However, the
mouse lung was identified as a major target organ in a chronic bioassay, with an oral gavage …

d-Limonene is a hyaline droplet inducing agent and produces nephrotoxicity in male rats
when the 1,2-epoxide metabolite binds to α2u-globulin. Mice, which do not synthesize α2u-…

The purpose of the present work was to characterize the effect of musk xylene (MX) and
musk ketone (MK) treatment on rat hepatic cytochrome P450 enzymes. Male F344 rats were …

Musk xylene (MX) (1,3,5-trinitro-2-t-butylxylene) is a nitromusk perfume ingredient that
although uniformly negative in a battery of genotoxicity tests, produces a high incidence of liver …