User profiles for Douglas H. Sweet
Douglas SweetE. Claiborne Robins Distinguished Professor and Chair, Virginia Commonwealth University Verified email at vcu.edu Cited by 5537 |
Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology
…, MR Gionfriddo, DH Sweet - Biopharmaceutics & drug …, 2010 - Wiley Online Library
Our understanding of the mechanisms behind inter‐ and intra‐patient variability in drug
response is inadequate. Advances in the cytochrome P450 drug metabolizing enzyme field have …
response is inadequate. Advances in the cytochrome P450 drug metabolizing enzyme field have …
The kidney and uremic toxin removal: glomerulus or tubule?
Chronic kidney disease (CKD) is a condition that affects approximately 10% of the adult
population in developed countries. In patients with CKD adequate renal clearance is …
population in developed countries. In patients with CKD adequate renal clearance is …
Renal organic anion transporters (SLC22 family): expression, regulation, roles in toxicity, and impact on injury and disease
Organic solute flux across the basolateral and apical membranes of renal proximal tubule
cells is a key process for maintaining systemic homeostasis. It represents an important route …
cells is a key process for maintaining systemic homeostasis. It represents an important route …
[HTML][HTML] Expression cloning and characterization of ROAT1: the basolateral organic anion transporter in rat kidney
DH Sweet, NA Wolff, JB Pritchard - Journal of Biological Chemistry, 1997 - ASBMB
Expression cloning in Xenopus laevisoocytes was used to isolate an organic anion transport
protein from rat kidney. A cDNA library was constructed from size-fractionated poly(A) + …
protein from rat kidney. A cDNA library was constructed from size-fractionated poly(A) + …
The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1
…, JB Pritchard, MD Fuller, DB Mendel, DH Sweet - Molecular …, 1999 - ASPET
Nephrotoxicity is the dose-limiting clinical adverse effect of cidofovir and adefovir, two potent
antiviral therapeutics. Because renal uptake likely plays a role in the etiology of cidofovir- …
antiviral therapeutics. Because renal uptake likely plays a role in the etiology of cidofovir- …
[HTML][HTML] Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice
DH Sweet, DS Miller, JB Pritchard, Y Fujiwara… - Journal of Biological …, 2002 - ASBMB
To begin to develop in vivo model systems for the assessment of the contributions of specific
organic anion transporter (OAT) family members to detoxification, development, and disease…
organic anion transporter (OAT) family members to detoxification, development, and disease…
[PDF][PDF] Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis
…, JA Johnson, GL Youngblood, DH Sweet… - The American Journal of …, 2008 - cell.com
The human carboxylesterase 1 (CES1) gene encodes for the enzyme carboxylesterase 1, a
serine esterase governing both metabolic deactivation and activation of numerous …
serine esterase governing both metabolic deactivation and activation of numerous …
Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+gradient
DH Sweet, LMS Chan, R Walden… - American Journal …, 2003 - journals.physiology.org
Basolateral uptake of organic anions in renal proximal tubule cells is indirectly coupled to
the Na + gradient through Na + -dicarboxylate cotransport and organic anion/dicarboxylate …
the Na + gradient through Na + -dicarboxylate cotransport and organic anion/dicarboxylate …
[PDF][PDF] The furan fatty acid metabolite CMPF is elevated in diabetes and induces β cell dysfunction
Gestational diabetes (GDM) results from failure of the β cells to adapt to increased metabolic
demands; however, the cause of GDM and the extremely high rate of progression to type 2 …
demands; however, the cause of GDM and the extremely high rate of progression to type 2 …
Organic anion transporter (Slc22a) family members as mediators of toxicity
DH Sweet - Toxicology and applied pharmacology, 2005 - Elsevier
Exposure of the body to toxic organic anions is unavoidable and occurs from both intentional
and unintentional sources. Many hormones, neurotransmitters, and waste products of …
and unintentional sources. Many hormones, neurotransmitters, and waste products of …