Issues and progress with protein kinase inhibitors for cancer treatment
J Dancey, EA Sausville - Nature reviews Drug discovery, 2003 - nature.com
Identification of the key roles of protein kinases in cancer has led to extensive efforts to
develop kinase inhibitors for the treatment of a wide range of cancers, and more than 30 such …
develop kinase inhibitors for the treatment of a wide range of cancers, and more than 30 such …
Preclinical and clinical development of cyclin-dependent kinase modulators
AM Senderowicz, EA Sausville - Journal of the National Cancer …, 2000 - academic.oup.com
… Editor's note: EA Sausville is a participant in the National Cancer Institute's Cooperative
Research and Development Agreement with Hoechst Marian Rousell that manufactures …
Research and Development Agreement with Hoechst Marian Rousell that manufactures …
Contributions of human tumor xenografts to anticancer drug development
EA Sausville, AM Burger - Cancer research, 2006 - AACR
… The review by Burger and Sausville makes the argument for the use of xenografts in
preclinical trials of anticancer therapeutics. Although the nature of the review was to take one …
preclinical trials of anticancer therapeutics. Although the nature of the review was to take one …
Proteasome inhibitors: a novel class of potent and effective antitumor agents
J Adams, VJ Palombella, EA Sausville, J Johnson… - Cancer research, 1999 - AACR
The ubiquitin-proteasome pathway plays a critical role in the regulated degradation of proteins
involved in cell cycle control and tumor growth. Dysregulating the degradation of such …
involved in cell cycle control and tumor growth. Dysregulating the degradation of such …
A gene expression database for the molecular pharmacology of cancer
…, DT Andrews, DA Scudiero, MB Eisen, EA Sausville… - Nature …, 2000 - nature.com
We used cDNA microarrays to assess gene expression profiles in 60 human cancer cell
lines used in a drug discovery screen by the National Cancer Institute. Using these data, we …
lines used in a drug discovery screen by the National Cancer Institute. Using these data, we …
Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials
…, S Arbuck, M Hollingshead, EA Sausville - British journal of …, 2001 - nature.com
An analysis of the activity of compounds tested in pre-clinical in vivo and in vitro assays by
the National Cancer Institute's Developmental Therapeutics Program was performed. For 39 …
the National Cancer Institute's Developmental Therapeutics Program was performed. For 39 …
An information-intensive approach to the molecular pharmacology of cancer
…, WW Van Osdol, AP Monks, DA Scudiero, EA Sausville… - Science, 1997 - science.org
Since 1990, the National Cancer Institute (NCI) has screened more than 60,000 compounds
against a panel of 60 human cancer cell lines. The 50-percent growth-inhibitory …
against a panel of 60 human cancer cell lines. The 50-percent growth-inhibitory …
Characterization of the p53 Tumor Suppressor Pathway in Cell Lines of the National Cancer Institute Anticancer Drug Screen and Correlations with the Growth …
…, S Fan, M Mutoh, DA Scudiero, A Monks, EA Sausville… - Cancer research, 1997 - AACR
In the present study, we report the characterization of the p53 tumor suppressor pathway in
the 60 cell lines of the National Cancer Institute (NCI) anticancer drug screen, as well as …
the 60 cell lines of the National Cancer Institute (NCI) anticancer drug screen, as well as …
Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin.
MR Bubb, AM Senderowicz, EA Sausville… - Journal of Biological …, 1994 - Elsevier
Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, Jaspis johnstoni,
has both fungicidal and antiproliferative activity. We now report that this peptide is a potent …
has both fungicidal and antiproliferative activity. We now report that this peptide is a potent …
Flavopiridol Induces G1 Arrest with Inhibition of Cyclin-dependent Kinase (CDK) 2 and CDK4 in Human Breast Carcinoma Cells
BA Carlson, MM Dubay, EA Sausville, L Brizuela… - Cancer research, 1996 - AACR
… J., Naik, R.. and Sausville. E. Growth inhibition with reversible cell cycle arrest of carcinoma
cells by flavone … M., Sehers, S., Sartor O., and Sausville, EA Alteration of the phosphorylation …
cells by flavone … M., Sehers, S., Sartor O., and Sausville, EA Alteration of the phosphorylation …