The heterocyclic amines (HCAs) are a family of mutagenic/carcinogenic compounds produced
during the pyrolysis of creatine, amino acids and proteins. The major subclass of HCAs …

Epidemiologic and experimental evidence indicates that dietary factors influence the incidence
of mammary gland cancer. The dietary causes of this cancer, however, remain largely …

The carcinogenic potential of 2‐amino‐3‐methylimidazo[4,5f]quinoline (IQ) was evaluated
in cynomolgus monkeys. Monkeys received IQ, beginning at the age of one year, at doses of …

… The contribution of hepatic and mammary gland metabolism to PhIP–DNA adduct formation
in the mammary gland was evaluated in several studies by Snyderwine and co-workers [24]. …

The most abundant heterocyclic amine in fried ground beef, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
(PhIP), induces colon carcinomas in the male F344 rat. The potential …

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a carcinogen found in cooked meat,
was determined to be a mammary carcinogen in female Sprague—Dawley rats on a high …

… Snyderwine, EG Some perspectives on the nutritional … and Snyderwine, EG Induction
of mammary tumors in female … HAJ, and Snyderwine, EG Enzymatic phase II activation of /V-…

… Factors that affect human heterocyclic amine intake, eg types of meat, cooking time, as
well as the influence of other dietary components on metabolic processing and excretion are …

… EG (1993) Studies on the mutagenic activation of heterocyclic amines by cynomolgus
monkey, rat and human microsomes show that monkeys have a low capacity to N-oxidize the …

Id4 belongs to a family of helix-loop-helix (HLH) proteins that impact cellular growth and
differentiation via regulation of basic HLH transcription factors. Herein the rat Id4 gene was …