Permeability is an important property of drug candidates. The Madin–Darby canine kidney
cell line (MDCK) permeability assay is widely used and the primary concern of using MDCK …

4-Anilinoquinazoline- and 4-anilinopyrido[3,2-d]pyrimidine-6-acrylamides substituted with
solubilizing 7-alkylamine or 7-alkoxyamine side chains were prepared by reaction of the …

Importance of the field: P-glycoprotein (P-gp) is the most characterized drug transporter in
terms of its clinical relevance for pharmacokinetic disposition and interaction with other …

In vitro and in situ experimental models that are descriptive of drug absorption in vivo are
valuable tools in the discovery of new chemical entities that are bioavailable after oral …

The effect of atorvastatin on digoxin pharmacokinetics was assessed in 24 healthy volunteers
in two studies. Subjects received 0.25 mg digoxin daily for 20 days, administered alone for …

The endothelins (ETs) are a family of bicyclic 21-amino acid peptides that are potent and
prolonged vasoconstrictors. It has been shown that highly potent combined ET A /ET B receptor …

Digoxin, an orally administered cardiac glycoside cardiovascular drug, has a narrow
therapeutic window. Circulating digoxin levels (maximal concentration of ∼1.5 ng/ml) require …

Axitinib is an inhibitor of tyrosine kinase vascular endothelin growth factor receptors 1, 2, and
3. The ATP-binding cassette (ABC) and solute carrier (SLC) transport properties of axitinib …

Incontinentia pigmenti (IP) is an X-linked dominant disorder characterized by developmental
anomalies of the tissues and organs derived from embryonic ectoderm and neuroectoderm. …

Bergamottin, a furanocoumarin isolated from grapefruit juice, was investigated for the ability
to increase diazepam bioavailability and for its effect on cytochrome P450 (P450) enzymes …