User profiles for E. M. Sellers

Edward M Sellers

University of Toronto
Verified email at dlglobalpartners.com
Cited by 45298

Drug disposition in old age

DJ Greenblatt, EM Sellers… - New England Journal of …, 1982 - Mass Medical Soc
THE appropriate and rational use of drugs by the elderly is a matter of growing medical and
social concern. Life expectancy in the Western world currently stands at 69 years for men …

Binding of drugs to serum albumin

J Koch-Weser, EM Sellers - New England Journal of Medicine, 1976 - Mass Medical Soc
Most drugs are carried from their sites of absorption to their sites of action and elimination by
the circulating blood. Some drugs are simply dissolved in serum water, but many others are …

Implications of CYP2A6 Genetic Variation for Smoking Behaviors and Nicotine Dependence

V Malaiyandi, EM Sellers… - Clinical Pharmacology & …, 2005 - Wiley Online Library
Nicotine is the primary addictive compound in tobacco smoke. In this review we summarize
nicotine dependence and the genetics of smoking in brief before focusing on cytochrome …

A method for estimating the probability of adverse drug reactions

CA Naranjo, U Busto, EM Sellers… - Clinical …, 1981 - Wiley Online Library
… Busto U, Naranjo CA, Sellers EM: Comparison of two recently published algorithms to assess
the probability of adverse drug reactions. CLIN PHARMACOL THER 29:236, 1981. Gross …

Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA‐Ar)

…, CA Naranjo, EM Sellers - British journal of …, 1989 - Wiley Online Library
A shortened 10‐item scale for clinical quantitation of the severity of the alcohol withdrawal
syndrome has been developed. This scale offers an increase in efficiency while at the same …

A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes

ES Messina, RF Tyndale, EM Sellers - Journal of Pharmacology and …, 1997 - ASPET
Nicotine is primarily metabolized to cotinine by cytochromes P450 (CYPs). The degree of
variation in the metabolism of nicotine to cotinine and the relative roles of the polymorphic …

[HTML][HTML] Nicotine metabolism defect reduces smoking

ML Pianezza, EM Sellers, RF Tyndale - Nature, 1998 - nature.com
Nicotine is the primary compound in tobacco that establishes and maintains tobacco dependence
1 . Most of this nicotine is metabolized to cotinine by the genetically variable enzyme …

Diazepam actions and plasma concentrations following ethanol ingestion

…, HG Giles, G Patzalek, JJ Thiessen, EM Sellers - European journal of …, 1977 - Springer
In eight normal volunteers, the combination of ethanol (0.5 g/kg) and diazepam (10 mg)
administered orally produced a greater decrease in motor performance on a pursuit rotor than …

Withdrawal reaction after long-term therapeutic use of benzodiazepines

U Busto, EM Sellers, CA Naranjo… - … England Journal of …, 1986 - Mass Medical Soc
We conducted a double-blind, placebo-controlled trial in which 40 patients who had undergone
long-term therapy with benzodiazepines were switched to placebo or to diazepam in a …

Measurement issues in postpartum depression part 1: anxiety as a feature of postpartum depression

LE Ross, SEG Evans, EM Sellers… - Archives of women's …, 2003 - Springer
We investigated the contribution of anxiety symptoms to scores on the Edinburgh Postnatal
Depression Scale (EPDS) between 36 weeks gestation and 16 weeks postpartum in 150 …