Mechanisms of aflatoxin carcinogenesis

DL Eaton, EP Gallagher - Annual review of pharmacology and …, 1994 - annualreviews.org
… In contrast, AFBI-GSH conjugation is not a significant route of AFBI detoxification in rainbow
trout (81), coho salmon (81), or channel catfish (EP Gallagher and DL Eaton, unpublished …

The role of biomarkers in the assessment of aquatic ecosystem health

SE Hook, EP Gallagher… - Integrated environmental …, 2014 - Wiley Online Library
… Evan P Gallagher … Evan P Gallagher … Recently, Williams and Gallagher (2013) linked
molecular biomarker encoding olfactory receptors and signal transduction components to …

Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity

DL Eaton, EP Gallagher, TK Bammler… - Pharmacogenetics and …, 1995 - journals.lww.com
Cytochrome P4501A2 (CYP1A2) has been identified as a key factor in the metabolic
activation of numerous chemical carcinogens, including afiatoxin B1, various heterocyclic and …

Effects of Black Rock Harbor sediments on indices of biotransformation, oxidative stress, and DNA integrity in channel catfish

RT Di Giulio, C Habig, EP Gallagher - Aquatic toxicology, 1993 - Elsevier
Selected biochemical responses were measured in channel catfish (Ictalurus punctatus)
exposed in the laboratory to sediments obtained from either of two sites in Long Island Sound, …

The kinetics of aflatoxin B1Oxidation by human cDNA-Expressed and human liver microsomal cytochromes P450 1A2 and 3A4

EP Gallagher, KL Kunze, PL Stapleton… - Toxicology and applied …, 1996 - Elsevier
The combined presence of CYP1A2 and 3A4, both of which oxidize aflatoxin B 1 (AFB 1 ) to
the reactive aflatoxin B 1 -8,9-epoxide (AFBO) and to hydroxylated inactivation products …

Role of Human Microsomal and Human Complementary DNA-expressed Cytochromes P4501A2 and P4503A4 in the Bioactivation of Aflatoxin B1

EP Gallagher, LC Wienkers, PL Stapleton, KL Kunze… - Cancer research, 1994 - AACR
The metabolism of the carcinogenic mycotoxin aflatoxin B 1 (AFB 1 ) was examined in
microsomes derived from human lymphoblastoid cell lines expressing transfected CYP1A2 or …

[PDF][PDF] Biotransformation in fishes

D Schlenk, M Celander, EP Gallagher… - The toxicology of …, 2008 - academia.edu
Biotransformation is a two-phase process catalyzed primarily through enzymatic reactions
that often radically alter the chemistry of nonpolar lipophilic chemicals to polar water-soluble …

Contaminants of emerging concern in a large temperate estuary

JP Meador, A Yeh, G Young, EP Gallagher - Environmental Pollution, 2016 - Elsevier
This study was designed to assess the occurrence and concentrations of a broad range of
contaminants of emerging concern (CECs) from three local estuaries within a large estuarine …

Species-specific differences and structure− activity relationships in the debromination of PBDE congeners in three fish species

SC Roberts, PD Noyes, EP Gallagher… - … science & technology, 2011 - ACS Publications
Previous studies have suggested that there may be species-specific differences in the metabolism
of polybrominated diphenyl ethers (PBDEs) among different fish species. In this study, …

Swimming impairment and acetylcholinesterase inhibition in zebrafish exposed to copper or chlorpyrifos separately, or as mixtures

FA Tilton, TK Bammler, EP Gallagher - … and Physiology Part C: Toxicology & …, 2011 - Elsevier
Pesticides such as chlorpyrifos (CPF) and metals such as copper can impair swimming
behavior in fish. However, the impact to swimming behavior from exposure to mixtures of …