ABOUT thirty years ago I read in the will of Lord Bacon-" For my burial, I desire it may be in St.
Michael's Church, St. Albans: there was my mother buried, and it is the parish church of my …

… Bacon ist vermutlich der erste Autor, der die empirische Erforschung des Alterns und seine
… Eine weitere medizinethische Besonderheit findet sich bei Bacon in diesem Kontext. Er hält …

Brain development is a life-long process that encompasses several critical periods of transition,
during which significant cognitive changes occur. Embryonic development, puberty, and …

Structural analysis of the essential binding elements of the oxindole-based kinase inhibitor (1)
led to the identification of a novel class of heterocyclic-substituted pyrazolones. …

KDR kinase inhibition is considered to play an important role in regulating angiogenesis,
which is vital for the survival and proliferation of tumor cells. Recently we disclosed a structure-…

Optimization of a novel series of pyridazin-3-one histamine H 3 receptor (H 3 R) antagonists/inverse
agonists identified 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-…

Cardiac glycosides (such as digitalis) have, historically, been used as positive inotropic agents
for the treatment of congestive heart failure, a chronic and debilitating disease. 1" 3 The …

While there is a great clinical need to understand the biology of metastatic cancer in order to
treat it more effectively, research is hampered by limited sample availability. Research …

CEP-26401 [irdabisant; 6-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2H-pyridazin-3-one
HCl] is a novel, potent histamine H 3 receptor (H 3 R) antagonist/inverse agonist with …

Perimenopause marks initiation of female reproductive senescence. Age of onset is only 47%
heritable suggesting that additional factors other than inheritance regulate this endocrine …