Using the broadest definition, the primary aim of all past risk evaluations was to protect the
public from potential adverse health effects of any anthropogenic activity. More recently risk …

Aldrin epoxidation was studied in rat liver microsomes. The assay is very sensitive; amounts
of less than 1 ag of microsomal protein were sufficient for activity determination. The very …

The concentrations of chlorinated dibenzodioxins and dibenzofurans (PCDD/F) in human
blood and in milk from non-occupationally exposed persons living in the vicinity of a municipal …

The gestagenic and antiandrogenic drug cyproterone acetate (CPA) is mitogenic, tumorigenic
and induces DNA-adducts and DNA-repair synthesis in rat liver. Thus CPA is expected to …

The promoting activity of the commercial PCB mixture Clophen A 50 on preneoplastic,
enzymealtered islands in rat liver was investigated. Female Sprague-Dawley rats, 3 and 6 weeks …

The rat liver foci bioassay designed as short-term screening test system in vivo is a reliable
procedure for the detection of the carcinogenic potential of chemicals. The use of tumor …

The promoting effect of Clophen A 50, a commercial mixture of polychlorinated biphenyis (PCBs)
on preneoplastic islands, initiated by diethylnitrosamine (DEN), was studied in male …

Cyproterone acetate (CPA) is a synthetic steroid which is used in oral contraceptive and anti-androgen
formulations. It has previously been classified as a tumor promoter in rat liver. …

… Wachstein M, Meisel E. Histochemistry of substrate specific phosphatases at a physiological
… Wolf E, Wanke R. Growth hormone overproduction in transgenic mice: phenotypic …

A rat liver foci bioassay (RLFB) based on an initiation-promotion protocol employing
preneoplastic foci of altered hepatocytes (FAH) as an endpoint, was prevalidated in 5 different …