[HTML][HTML] Microvascular endothelial cell heterogeneity: general concepts and pharmacological consequences for anti-angiogenic therapy of cancer
E Langenkamp, G Molema - Cell and tissue research, 2009 - Springer
… In situ in the umbilical cord, transcription factor and p300 coactivator recruitment to the
enhancer sequence in the E-selectin promoter was reduced in the artery endothelial cells …
enhancer sequence in the E-selectin promoter was reduced in the artery endothelial cells …
VEGF suppresses T‐lymphocyte infiltration in the tumor microenvironment through inhibition of NF‐κB‐induced endothelial activation
H Huang, E Langenkamp, M Georganaki… - The FASEB …, 2015 - Wiley Online Library
… It is notable that TNF-a-induced expression of ICAM-1, VCAM-1, and E-selectin was not
detected as significantly repressed by VEGF cotreatment in our microarray analysis of HDMEC. …
detected as significantly repressed by VEGF cotreatment in our microarray analysis of HDMEC. …
Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF‐A and TGFβ2 in vascular abnormalization
LC Dieterich, S Mellberg, E Langenkamp… - The Journal of …, 2012 - Wiley Online Library
Glioblastoma are aggressive astrocytic brain tumours characterized by microvascular
proliferation and an abnormal vasculature, giving rise to brain oedema and increased patient …
proliferation and an abnormal vasculature, giving rise to brain oedema and increased patient …
Identification of epigenetically silenced genes in tumor endothelial cells
DMEI Hellebrekers, V Melotte, E Viré, E Langenkamp… - Cancer research, 2007 - AACR
Tumor angiogenesis requires intricate regulation of gene expression in endothelial cells.
We recently showed that DNA methyltransferase (DNMT) and histone deacetylase (HDAC) …
We recently showed that DNA methyltransferase (DNMT) and histone deacetylase (HDAC) …
Elevated expression of the C-type lectin CD93 in the glioblastoma vasculature regulates cytoskeletal rearrangements that enhance vessel function and reduce host …
Glioblastoma is an aggressive brain tumor characterized by an abnormal blood vasculature
that is hyperpermeable. Here, we report a novel role for CD93 in regulating angiogenesis in …
that is hyperpermeable. Here, we report a novel role for CD93 in regulating angiogenesis in …
Innovations in studying in vivo cell behavior and pharmacology in complex tissues–microvascular endothelial cells in the spotlight
E Langenkamp, JAAM Kamps, M Mrug… - Cell and tissue …, 2013 - Springer
Many studies on the molecular control underlying normal cell behavior and cellular responses
to disease stimuli and pharmacological intervention are conducted in single-cell culture …
to disease stimuli and pharmacological intervention are conducted in single-cell culture …
Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction
…, MH de Jager, R Camacho, E Langenkamp… - Drug metabolism and …, 2006 - ASPET
Tissue slices have been shown to be a valuable tool to predict metabolism of novel drugs.
However, besides the numerous advantages of their use for this purpose, some potential …
However, besides the numerous advantages of their use for this purpose, some potential …
[HTML][HTML] Tumor vascular morphology undergoes dramatic changes during outgrowth of B16 melanoma while proangiogenic gene expression remains unchanged
E Langenkamp, FM Vom Hagen, PJ Zwiers… - International Scholarly …, 2011 - hindawi.com
In established tumors, angiogenic endothelial cells (ECs) coexist next to “quiescent” EC in
matured vessels. We hypothesized that angio-gene expression of B16.F10 melanoma would …
matured vessels. We hypothesized that angio-gene expression of B16.F10 melanoma would …
Vascular endothelial growth factor receptor 2 inhibition in-vivo affects tumor vasculature in a tumor type-dependent way and downregulates vascular endothelial …
E Langenkamp, PJ Zwiers, HE Moorlag… - Anti-Cancer …, 2012 - journals.lww.com
The precise molecular effects that antiangiogenic drugs exert on tumor vasculature remain
to be poorly understood. We therefore set out to investigate the molecular and architectural …
to be poorly understood. We therefore set out to investigate the molecular and architectural …
[BOOK][B] Lock-in thermography: Basics and use for evaluating electronic devices and materials
O Breitenstein, W Warta, M Langenkamp - 2010 - Springer
This book discusses lock-in thermography (LIT) as a dynamic variant of the widely known IR
thermography. It focuses on applications to electronic devices and materials, but also …
thermography. It focuses on applications to electronic devices and materials, but also …