The human CYP3A subfamily plays a dominant role in the metabolic elimination of more
drugs than any other biotransformation enzyme. CYP3A enzyme is localized in the liver and …

Tacrolimus is a substrate for P-glycoprotein (P-gp) and cytochrome (CYP) P4503A. P-gp is
encoded by the multiple drug resistance gene MDR1 and CYP3A is the major enzyme …

… to a TK-luciferase reporter transiently transfected into LS180 cells (E. Schuetz, unpublished).
Mutation of the PXRE element abrogates vitamin D 3 activation of the CYP3A4 promoter (E. …

Variation in the CYP3A enzymes, which act in drug metabolism, influences circulating steroid
levels and responses to half of all oxidatively metabolized drugs. CYP3A activity is the sum …

MDR1 (P‐glycoprotein) is an important factor in the disposition of many drugs, and the
involved processes often exhibit considerable interindividual variability that may be genetically …

Genetic variants that are associated with common human diseases do not lead directly to
disease, but instead act on intermediate, molecular phenotypes that in turn induce changes in …

A variety of cytokines mediate the activation of Janus protein tyrosine kinases (Jaks). The
Jaks then phosphorylate cellular substrates, including members of the signal transducers and …

Xenobiotics frequently induce proteins involved in their detoxification. Because many drugs
that are metabolized by human cytochromes P450 (CYP) 3A4 and 3A5 are also transported …

We used monoclonal antibodies and complementary DNAs (cDNAs) to glucocorticoid-inducible
liver cytochromes P-450 in rats (P-450p) and in man (HLp) to search for related …

We recently demonstrated that a variant allele of CYP3A5(CYP3A5*3) confers low CYP3A5
expression as a result of improper mRNA splicing. In this study, we further evaluated the …