… The use of tritiated compounds to support drug discovery is not new though and was being
routinely used by pharmaceutical companies (E. Solon, presented at the European Society …

Radioactivity has been used in drug discovery and development for several decades
because it offers researchers a highly sensitive way to quantitatively assess the absorption, …

… radioactive autoradiography calibration standards require re-calibration before use because
they are well-known to have inaccurate concentration values assigned to them; Solon and …

… a thesis submitted by E. Solon in partial fulfillment of the requirements for the degree of Ph.D…
and various solvents containing 0.1 M LiC104 by measuring the E¡/, for the oxidation of 4,7-…

… analysis system maintained an electronic audit trail. Most … analysis systems maintained
complete electronic audit trails, … documentation of any changes made to the electronic data. …

… KB-E. and DA provided guidance on the program and review of the data. Richard Perry
provided editorial assistance in the finalization and submission of the manuscript. …

… imaging are scanned into a PC image analysis system [6] and images, which reflect the
concentration of radioactivity within the sections, are printed and saved digitally as electronic files…

Autoradiography (ARG) is a powerful, high resolution, quantitative molecular imaging technique
used to study the tissue distribution of radiolabeled xenobiotics in biologic models. ARG …

Targeting host functions essential for viral replication has been considered as a broad
spectrum and resistance-refractory antiviral approach. However, only a few host functions have, …

Penetration of dalbavancin into noninfected bone and joint tissues was assessed after an
intravenous dose of 20 mg/kg (of body weight) [ 14 C]dalbavancin given to rabbits. Drug-…