Precision-cut tissue slices (PCTS) are viable ex vivo explants of tissue with a reproducible,
well defined thickness. They represent a mini-model of the organ under study and contain all …

The performance of the Flash DSC 1, a recently introduced, commercial available chip fast
scanning calorimeter (FSC) based on MEMS sensor technology, was studied. Topics …

Background Chronic postsurgical pain can severely impair patient health and quality of life.
This systematic review update evaluated the effectiveness of systemic drugs to prevent …

Although the liver has long been thought to play the major role in drug metabolism, also the
metabolic capacity of the intestine is more and more recognized. In vivo studies eventually …

Predictive in vitro methods to investigate drug metabolism in the human intestine using intact
tissue are of high importance. Therefore, we studied the metabolic activity of human small …

This paper reports on the temperature calibration and electrical characterization of the
calorimeter chip UFS1 (internal design XI-400) developed for the new commercially available …

Induction of drug enzyme activity in the intestine can strongly determine plasma levels of
drugs. It is therefore important to predict drug-drug interactions in human intestine in vitro. We …

Introduction: A new technique was developed to prepare precision-cut slices from small
intestine and colon with the object of studying the biotransformation of drugs in these organs. …

Importance To improve diagnostics of cancer predisposition syndromes (CPSs) in children
with cancer, it is essential to evaluate the effect of CPS gene sequencing among all children …

The aim of this study was to characterize rat small intestinal and colon tissue slices as a tool
to study intestinal metabolism and to investigate gradients of drug metabolism along the …