Objective To evaluate whether penetration of a combination regimen into the central
nervous system (CNS), as estimated by the CNS Penetration-Effectiveness (CPE) rank, is …

Background Childhood absence epilepsy, the most common pediatric epilepsy syndrome,
is usually treated with ethosuximide, valproic acid, or lamotrigine. The most efficacious and …

Objective. To determine the prevalence and outcome of intravenous gamma-globulin (IVIG)
retreatment in patients with Kawasaki disease (KD). Method. Multicenter, retrospective …

Background The discovery of potent and broadly neutralizing antibodies (bNAbs) against
human immunodeficiency virus (HIV) has made passive immunization a potential strategy for …

Passive immunization with HIV-1–neutralizing monoclonal antibodies (mAbs) is being
considered for prevention and treatment of HIV-1 infection. As therapeutic agents, mAbs could be …

Background. Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND)
can show variable clinical trajectories. Previous longitudinal studies of HAND typically …

Recent advances in neurobiology and clinical medicine have established that the fetus and
newborn may experience acute, established, and chronic pain. They respond to such …

Background New approaches for the prevention and elimination of malaria, a leading cause
of illness and death among infants and young children globally, are needed. Methods We …

Background Additional interventions are needed to reduce the morbidity and mortality caused
by malaria. Methods We conducted a two-part, phase 1 clinical trial to assess the safety …

OBJECTIVE: To investigate the safety, tolerability, and pharmacokinetics of the anti–tumor
necrosis factor-α monoclonal antibody infliximab in subjects with intravenous immunoglobulin …