Bioactivation of Tegafur to 5-Fluorouracil Is Catalyzed by Cytochrome P-450 2A6 in Human Liver Microsomes in Vitro
K Ikeda, K Yoshisue, E Matsushima, S Nagayama… - Clinical cancer …, 2000 - AACR
Tegafur is a prodrug of 5-fluorouracil (5-FU) consisting of a new class of oral chemotherapeutic
agents, tegafur/uracil and S-1, which are classified as dihydropyrimidine dehydrogenase …
agents, tegafur/uracil and S-1, which are classified as dihydropyrimidine dehydrogenase …
Pressure and temperature control of product chirality in asymmetric photochemistry. Enantiodifferentiating photoisomerization of cyclooctene sensitized by chiral …
Y Inoue, E Matsushima, T Wada - Journal of the American …, 1998 - ACS Publications
Pressure effects upon asymmetric photosensitization have been investigated for the first time
in the enantiodifferentiating Z−E photoisomerization of cyclooctene (1), sensitized by chiral …
in the enantiodifferentiating Z−E photoisomerization of cyclooctene (1), sensitized by chiral …
First-in-human, phase I dose-escalation study of single and multiple doses of a first-in-class enhancer of fluoropyrimidines, a dUTPase inhibitor (TAS-114) in healthy …
…, K Yoshisue, T Yokogawa, E Matsushima… - Cancer chemotherapy …, 2014 - Springer
Purpose TAS-114 is a first-in-class oral deoxyuridine triphosphatase (dUTPase) inhibitor,
which acts as a modulator of the pyrimidine nucleotide metabolic pathway. This was a first-in-…
which acts as a modulator of the pyrimidine nucleotide metabolic pathway. This was a first-in-…
Determination of S-1 (combined drug of tegafur, 5-chloro-2, 4-dihydroxypyridine and potassium oxonate and 5-fluorouracil in human plasma and urine using high …
E Matsushima, K Yoshida, R Kitamura… - … of Chromatography B …, 1997 - Elsevier
A high-performance liquid chromatography (HPLC) and gas chromatography-negative ion
chemical ionization mass spectrometry (GC-NICI-MS) method was developed for the analysis …
chemical ionization mass spectrometry (GC-NICI-MS) method was developed for the analysis …
Multiscale study on thermal insulating effect of a hollow silica-coated polycarbonate window for residential buildings
Y Uetsuji, Y Yasuda, S Yamauchi, E Matsushima… - … and Sustainable Energy …, 2021 - Elsevier
To support the sustainable development of housing in a low-carbon society, this paper
presents a multiscale simulation that connects material development at microscale, structural …
presents a multiscale simulation that connects material development at microscale, structural …
TAS-114, a first-in-class dual dUTPase/DPD inhibitor, demonstrates potential to improve therapeutic efficacy of fluoropyrimidine-based chemotherapy
…, A Fujioka, K Yoshisue, E Matsushima… - Molecular cancer …, 2018 - AACR
5-Fluorouracil (5-FU) is an antimetabolite and exerts antitumor activity via intracellularly and
physiologically complicated metabolic pathways. In this study, we designed a novel small …
physiologically complicated metabolic pathways. In this study, we designed a novel small …
Tissue distribution and biotransformation of potassium oxonate after oral administration of a novel antitumor agent (drug combination of tegafur, 5-chloro-2, 4 …
K Yoshisue, H Masuda, E Matsushima, K Ikeda… - Drug metabolism and …, 2000 - ASPET
S-1, a new oral 5-fluorouracil (5-FU)-derivative antitumor agent, is composed of tegafur, 5-chloro-2,4-dihydropyridine,
and potassium oxonate (Oxo). Oxo, which inhibits the …
and potassium oxonate (Oxo). Oxo, which inhibits the …
The threshold of pain and neurotransmitter's change on pain in Parkinson's disease
K Urakami, K Takahashi, E Matsushima… - Psychiatry and …, 1990 - Wiley Online Library
Among Parkinson's disease (PD) patients complaining of pain, 10 with pain not associated
with a motor fluctuation or L‐dopa therapy were evaluated. The controls were 14 PD without …
with a motor fluctuation or L‐dopa therapy were evaluated. The controls were 14 PD without …
Improvement in precision of the liquid chromatographic–electrospray ionization tandem mass spectrometric analysis of 3′-C-ethynylcytidine in rat plasma
R Kitamura, K Matsuoka, E Matsushima… - … of Chromatography B …, 2001 - Elsevier
During the development of the liquid chromatography with electrospray ionization–tandem
mass spectrometry for the quantitative determination of 3′-C-ethynylcytidine (I) in rat plasma, …
mass spectrometry for the quantitative determination of 3′-C-ethynylcytidine (I) in rat plasma, …
Decreased superoxide dismutase activity in erythrocyte in Parkinson's disease
K Urakami, K Sano, E Matsushima… - Psychiatry and …, 1992 - Wiley Online Library
Superoxide dismutase (SOD) activities in Parkineon's disease (PD) were significantly lower
than those in controls, especially in a treated PD group. However, SOD activities in an …
than those in controls, especially in a treated PD group. However, SOD activities in an …