User profiles for Eleni Aklillu
 | Eleni AklilluProfessor of Tropical Pharmacology, Karolinska Institutet Verified email at ki.se Cited by 9593 |
PharmGKB summary: very important pharmacogene information for: N:-acetyltransferase 2
EM McDonagh, S Boukouvala, E Aklillu… - Pharmacogenetics …, 2014 - journals.lww.com
Background Function and expression Arylamine N-acetyltransferases (NATs) are
xenobioticmetabolizing enzymes for which three distinct enzymatic activities have been described …
xenobioticmetabolizing enzymes for which three distinct enzymatic activities have been described …
Towards host-directed therapies for tuberculosis
…, V Rasolofo, P Munderi, N Singh, E Aklillu… - Nature reviews Drug …, 2015 - nature.com
The treatment of tuberculosis is based on combinations of drugs that directly target
Mycobacterium tuberculosis. A new global initiative is now focusing on a complementary …
Mycobacterium tuberculosis. A new global initiative is now focusing on a complementary …
[HTML][HTML] Global Tuberculosis Report 2020–Reflections on the Global TB burden, treatment and prevention efforts
J Chakaya, M Khan, F Ntoumi, E Aklillu… - International journal of …, 2021 - Elsevier
The October 2020 Global TB report reviews TB control strategies and United Nations (UN)
targets set in the political declaration at the September 2018 UN General Assembly high-level …
targets set in the political declaration at the September 2018 UN General Assembly high-level …
A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants
SC Sim, C Risinger, ML Dahl, E Aklillu… - Clinical …, 2006 - Wiley Online Library
Background and Objective Many drugs, including proton pump inhibitors and certain
antidepressants, are metabolized by the polymorphic cytochrome P450 (CYP) 2C19 enzyme. A …
antidepressants, are metabolized by the polymorphic cytochrome P450 (CYP) 2C19 enzyme. A …
[PDF][PDF] Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles.
E Aklillu, I Persson, L Bertilsson… - … of pharmacology and …, 1996 - researchgate.net
The debrisoquine hydroxylase(CYP2D6) catalyzes the oxidative metabolism of more than 40
different clinically important drugs. The CYP2D6 gene is highly polymorphic. Defect alleles, …
different clinically important drugs. The CYP2D6 gene is highly polymorphic. Defect alleles, …
Emergence of new SARS-CoV-2 Variant of Concern Omicron (B. 1.1. 529)-highlights Africa's research capabilities, but exposes major knowledge gaps, inequities of …
Nearly two years since the start of the SARS-CoV-2 pandemic, which has caused over 5
million deaths, the world continues to be on high COVID-19 alert. The World Health …
million deaths, the world continues to be on high COVID-19 alert. The World Health …
Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans
…, HK Roh, M Ingelman-Sundberg, E Aklillu… - European journal of …, 2007 - Springer
Objectives To investigate the CYP1A2 genotype-phenotype relationship and to compare
CYP1A2 genetic polymorphisms and enzyme activity in terms of the effect of smoking and oral …
CYP1A2 genetic polymorphisms and enzyme activity in terms of the effect of smoking and oral …
Genetic polymorphism of cytochrome P450 2C9 in a Caucasian and a black African population
Aims CYP2C9 is a major enzyme in human drug metabolism and the polymorphism observed
in the corresponding gene may affect the therapeutic outcome during treatment with …
in the corresponding gene may affect the therapeutic outcome during treatment with …
The impact of first-line anti-tubercular drugs' pharmacokinetics on treatment outcome: a systematic review
…, E Tadesse, E Makonnen, E Aklillu - Clinical pharmacology …, 2021 - Taylor & Francis
Background Tuberculosis remains the major public health problem besides tremendous
efforts to combat it. Most tuberculosis patients are treated with a standard dose of first-line anti-…
efforts to combat it. Most tuberculosis patients are treated with a standard dose of first-line anti-…
Genetic polymorphism of CYP1A2 in Ethiopians affecting induction and expression: characterization of novel haplotypes with single-nucleotide polymorphisms in …
CYP1A2 polymorphism has been well studied in white persons and Asians but not in Africans.
We performed CYP1A2 genotype and phenotype analysis using caffeine in Ethiopians …
We performed CYP1A2 genotype and phenotype analysis using caffeine in Ethiopians …