We determined the disposition of a single 300-mg dose of [ 14 C]celecoxib in eight healthy
male subjects. The [ 14 C]celecoxib was administered as a fine suspension reconstituted in …

A pharmacokinetics and metabolism study was conducted in eight healthy human volunteers.
After oral administration of [ 14 C]eplerenone (EP) at a dose of 100 mg per person as an …

Flavopiridol, the first potent cyclin-dependent kinase inhibitor to enter clinical trials, was
recently found to be cytotoxic to noncycling cells. The present studies were performed to …

Analysis of the reaction between 2‘-deoxyadenosine and 4-oxo-2-nonenal by liquid
chromatography/mass spectrometry revealed the presence of three major products (adducts A 1 , A …

The metabolic fate of SC-57461, N-methyl-N-[3-[4-(phenylmethyl)-phenoxyjpropyl]-fi-alanine,
a potent and specific inhibitor of the leukotriene A, hydrolase, was determined by LC/MS/…

… I am indebted to Roy Bible, Elisabeth Hajdu, and GD Searle for the deuterium decoupled
500 MHz NMR spectra. I also thank the National Science Foundation, the Organic Division of …

… Damascus, under whose supervision all spectral data , were determined, to Luis Garcia,
Elisabeth Hajdu and Joan Lechwar for determination of the NMR spectra, to Emanual J. …

The reactions of mesoionic oxazolium 5-oxides (munchnones) derived from 1, 2, 3, 4-tetrahydroisoquinoline-lcarboxylic
acids (la, lb, and 5) are reported and involve the 1, 3-dipolar …

… The 1OOMHz NMR spectra were determined by Elisabeth Hajdu and Charles N. Fabler.
Spectroscopic data not given in this part are given in the table in the Spectroscopy Discussion …

Fractures of the head and neck of the femur in children are very rare, occurring only after a
high-velocity trauma, eg a fall from a height. This analysis shows the clinical course of …