Methyl donor deficiency impairs fatty acid oxidation through PGC-1α hypomethylation and decreased ER-α, ERR-α, and HNF-4α in the rat liver
…, JM Alberto, RM Guéant-Rodriguez, E Jeannesson… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: Folate and cobalamin are methyl donors needed for the synthesis
of methionine, which is the precursor of S-adenosylmethionine, the substrate of methylation …
of methionine, which is the precursor of S-adenosylmethionine, the substrate of methylation …
Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC‐1α by PRMT1 and SIRT1
…, P Brachet, JM Alberto, E Jeannesson… - The Journal of …, 2011 - Wiley Online Library
Cardiomyopathies occur by mechanisms that involve inherited and acquired metabolic
disorders. Both folate and vitamin B12 deficiencies are associated with left ventricular dysfunction…
disorders. Both folate and vitamin B12 deficiencies are associated with left ventricular dysfunction…
Long-term ACE inhibitor/ARB use is associated with severe renal dysfunction and acute kidney injury in patients with severe COVID-19: results from a referral center …
…, BM Caillierez, M Merten, E Jeannesson… - Clinical Infectious …, 2020 - academic.oup.com
Background In patients with severe coronavirus disease 2019 (COVID-19), data are scarce
and conflicting regarding whether chronic use of angiotensin-converting enzyme inhibitor (…
and conflicting regarding whether chronic use of angiotensin-converting enzyme inhibitor (…
Enzymes and pharmacogenetics of cardiovascular drugs
G Siest, E Jeannesson, S Visvikis-Siest - Clinica chimica acta, 2007 - Elsevier
To select the best drug for a patient, physicians can use pharmacogenomics to optimize the
effective drug and to minimize adverse reactions. Many enzymes are involved in the …
effective drug and to minimize adverse reactions. Many enzymes are involved in the …
Vitamin B12 deficiency reduces proliferation and promotes differentiation of neuroblastoma cells and up-regulates PP2A, proNGF, and TACE
…, N Noel, JM Alberto, E Jeannesson… - Proceedings of the …, 2009 - National Acad Sciences
Vitamin B12 (cobalamin, Cbl) is indispensable for proper brain development and functioning,
suggesting that it has neurotrophic effects beside its well-known importance in metabolism. …
suggesting that it has neurotrophic effects beside its well-known importance in metabolism. …
Transcription factor and drug-metabolizing enzyme gene expression in lymphocytes from healthy human subjects
G Siest, E Jeannesson, JB Marteau, A Samara… - Drug metabolism and …, 2008 - ASPET
We aimed to measure simultaneously the expression of drug-metabolizing enzymes (DME)
and transcription factors (TF) with high importance in cardiovascular physiopathology in …
and transcription factors (TF) with high importance in cardiovascular physiopathology in …
[HTML][HTML] Cardiovascular manifestations of intermediate and major hyperhomocysteinemia due to vitamin B12 and folate deficiency and/or inherited disorders of one …
…, A Oussalah, E Jeannesson… - The American journal of …, 2021 - Elsevier
Background The association of moderate hyperhomocysteinemia (HHcy) (15–30 μmol/L)
with cardiovascular diseases (CVD) has been challenged by the lack of benefit of vitamin …
with cardiovascular diseases (CVD) has been challenged by the lack of benefit of vitamin …
[HTML][HTML] The spectrum of biochemical alterations associated with organ dysfunction and inflammatory status and their association with disease outcomes in severe …
…, BM Caillierez, M Merten, E Jeannesson… - …, 2020 - thelancet.com
Background In patients with severe COVID-19, no data are available on the longitudinal
evolution of biochemical abnormalities and their ability to predict disease outcomes. Methods …
evolution of biochemical abnormalities and their ability to predict disease outcomes. Methods …
Folate‐ and vitamin B12‐deficient diet during gestation and lactation alters cerebellar synapsin expression via impaired influence of estrogen nuclear receptor α
…, A Geoffroy, E Jeannesson… - The FASEB …, 2015 - Wiley Online Library
Deficiency in the methyl donors vitamin B 12 and folate during pregnancy and postnatal life
impairs proper brain development. We studied the consequences of this combined …
impairs proper brain development. We studied the consequences of this combined …
Pharmacogenomics and cardiovascular drugs: need for integrated biological system with phenotypes and proteomic markers
…, S Maumus, H Berrahmoune, E Jeannesson… - European journal of …, 2005 - Elsevier
Personalized medicine is based on a better knowledge of biological variability, considering
the important part due to genetics. When trying to identify involved genes and their products …
the important part due to genetics. When trying to identify involved genes and their products …