Population differences in major functional polymorphisms of pharmacokinetics/pharmacodynamics-related genes in Eastern Asians and Europeans: implications in …
K Kurose, E Sugiyama, Y Saito - Drug metabolism and …, 2012 - jstage.jst.go.jp
Drug lag, recently discussed extensively in Japan, can be divided into two phases: clinical
development time and application review time. The former factor is still an important problem …
development time and application review time. The former factor is still an important problem …
[PDF][PDF] Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism
E Sugiyama, N Kaniwa, SR Kim… - Journal of Clinical …, 2007 - researchgate.net
Purpose Gemcitabine is rapidly metabolized to its inactive metabolite, 2, 2-difluorodeoxyuridine
(dFdU), by cytidine deaminase (CDA). We previously reported that a patient with …
(dFdU), by cytidine deaminase (CDA). We previously reported that a patient with …
[HTML][HTML] Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement
…, Y Saito, H Sawai, H Miyadera, E Sugiyama… - Scientific reports, 2014 - nature.com
Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN),
are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold …
are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold …
Specific HLA types are associated with antiepileptic drug-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese subjects
N Kaniwa, E Sugiyama, Y Saito, K Kurose… - …, 2013 - Future Medicine
Aim: This preliminary study investigated genomic biomarkers for Stevens–Johnson syndrome
(SJS) and toxic epidermal necrolysis (TEN), related to three antiepileptic drugs, zonisamide…
(SJS) and toxic epidermal necrolysis (TEN), related to three antiepileptic drugs, zonisamide…
IKZF1, a new susceptibility gene for cold medicine–related Stevens-Johnson syndrome/toxic epidermal necrolysis with severe mucosal involvement
Background Stevens-Johnson syndrome (SJS) and its severe form, toxic epidermal
necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous …
necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous …
Severe Drug Toxicity Associated with a Single-Nucleotide Polymorphism of the Cytidine Deaminase Gene in a Japanese Cancer Patient Treated with Gemcitabine …
…, N Saijo, T Yoshida, H Ishii, J Furuse, E Sugiyama… - Clinical cancer …, 2005 - AACR
Purpose: We investigated single-nucleotide polymorphisms of the cytidine deaminase gene
(CDA), which encodes an enzyme that metabolizes gemcitabine, to clarify the relationship …
(CDA), which encodes an enzyme that metabolizes gemcitabine, to clarify the relationship …
Substrate-dependent functional alterations of seven CYP2C9 variants found in Japanese subjects
K Maekawa, N Harakawa, E Sugiyama, M Tohkin… - Drug metabolism and …, 2009 - ASPET
CYP2C9 is a polymorphic enzyme that metabolizes a number of clinically important drugs.
In this study, catalytic activities of seven alleles found in Japanese individuals, CYP2C9*3 (…
In this study, catalytic activities of seven alleles found in Japanese individuals, CYP2C9*3 (…
Population pharmacokinetics of gemcitabine and its metabolite in Japanese cancer patients: impact of genetic polymorphisms
E Sugiyama, N Kaniwa, SR Kim, R Hasegawa… - Clinical …, 2010 - Springer
Background and Objective Gemcitabine (2′,2’-difluorodeoxycytidine) is an anticancer drug,
which is effective against solid tumours, including non-small-cell lung cancer and …
which is effective against solid tumours, including non-small-cell lung cancer and …
Development of a rapid and inexpensive assay for detecting a surrogate genetic polymorphism of HLA-B* 58: 01: a partially predictive but useful biomarker for …
…, J Nishikawa, N Kaniwa, E Sugiyama… - Drug metabolism and …, 2012 - Elsevier
Allopurinol-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) is
strongly associated with HLA-B*58:01 in various populations including Japanese. We …
strongly associated with HLA-B*58:01 in various populations including Japanese. We …
[HTML][HTML] Survival prediction for pancreatic cancer patients receiving gemcitabine treatment
…, T Okusaka, J Furuse, K Furuta, E Sugiyama… - Molecular & Cellular …, 2010 - ASBMB
Although gemcitabine monotherapy is the standard treatment for advanced pancreatic cancer,
patient outcome varies significantly, and a considerable number do not benefit adequately…
patient outcome varies significantly, and a considerable number do not benefit adequately…