Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg

SM Vidal, D Malo, K Vogan, E Skamene, P Gros - Cell, 1993 - Elsevier
Natural resistance to Infection with intracellular parasites is controlled by a dominant gene
on mouse chromosome 1, called Bcg, Lsh, or Ity. Bcg affects the capacity of macrophages to …

Anti-tumour necrosis factor agents and tuberculosis risk: mechanisms of action and clinical management

…, R Menzies, S Manners, E Skamene… - The Lancet infectious …, 2003 - thelancet.com
Cases of active tuberculosis have been reported worldwide with the use of therapeutic
agents that inhibit tumour necrosis factor (TNF) α. TNFα has a central role in mycobacterial …

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.

…, G Sebastiani, D Malo, E Skamene… - The Journal of …, 1995 - rupress.org
In mice, natural resistance or susceptibility to infection with intracellular parasites is
determined by a locus or group of loci on chromosome 1, designated Bcg, Lsh, and Ity, which …

[HTML][HTML] Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells

…, I Meunier, BK Davis, JPY Ting, E Skamene… - PLoS …, 2013 - journals.plos.org
Influenza A virus (IAV) triggers a contagious and potentially lethal respiratory disease. A
protective IL-1β response is mediated by innate receptors in macrophages and lung epithelial …

Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression.

…, N Groulx, J Liu, F Sanchez, E Skamene… - The Journal of …, 1994 - rupress.org
Natural resistance to infection with unrelated intracellular parasites such as Mycobacteria,
Salmonella, and Leishmania is controlled in the mouse by a single gene on chromosome 1, …

Susceptibility to Leprosy Is Linked to the Human NRAMP1 Gene

…, NV Thuc, LV Hoa, VD Lap, E Skamene… - Journal of Infectious …, 1998 - academic.oup.com
Leprosy is a debilitating infectious disease of human skin and nerves. Genetic factors of the
host play an important role in the manifestation of disease susceptibility. The human …

Genetic regulation of resistance to intracellular pathogens

E Skamene, P Gros, A Forget, PAL Kongshavn… - Nature, 1982 - nature.com
Natural resistance of mice to infections with Salmonella typhimurium and Leishmania donovani
is regulated by chromosome 1 gene(s) designated Ity and Lsh, respectively 1,2 . Given …

Dietary n-3 polyunsaturated fatty acids prevent the development of atherosclerotic lesions in mice. Modulation of macrophage secretory activities.

G Renier, E Skamene, J DeSanctis… - … and Thrombosis: A …, 1993 - Am Heart Assoc
We examined the effects of dietary n-3 polyunsaturated and saturated fatty acids on the
development of the atherogenic process in mice and on the macrophage ability to secrete …

Natural resistance to infection with intracellular parasites: molecular genetics identifies Nramp1 as the Bcg/Ity/Lsh locus

S Vidal, P Gros, E Skamene - Journal of Leukocyte Biology, 1995 - Wiley Online Library
Natural resistance to infection with intracellular parasites is controlled in the mouse by the
expression of a locus or group of loci on chromosome 1 alternatively named Bcg, Lsh, and Ity. …

Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice

…, G Leveque, L Larivière, L Laroche, E Skamene… - Genomics, 2000 - Elsevier
Toll-like receptors (TLRs) are a group of evolutionarily conserved pattern recognition receptors
involved in the activation of the immune system in response to various pathogens. In this …