Hypervalent azido- and cyanosilicate derivatives, prepared in situ by the reaction of
trimethylsilyl azide or trimethylsilyl cyanide, respectively, with tetrabutylammonium fluoride, are …

The greatest challenge standing in the way of effective in vivo siRNA delivery is creating a
delivery vehicle that mediates a high degree of efficacy with a broad therapeutic window. Key …

The disposition of vorinostat, an anticancer agent, was investigated in rats and dogs. Vorinostat
possessed high serum clearance, a short elimination half-life and low oral bioavailability …

The application of small interfering (si)RNAs as potential therapeutic agents requires safe
and effective methods for their delivery to the cytoplasm of the target cells and tissues. Recent …

The 2,3-diaminopyridine (DAP) moiety was found to represent a core structure essential for
the potency of a new series of human bradykinin B 1 receptor antagonists. However, …

(3R)-4-(4-Chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl
acetic acid (MK-0524) is a potent orally active human prostaglandin D 2 receptor 1 …

[(3R)-4-(4-Chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopentaindol-3-yl]acetic
acid (MK-0524) is a potent orally active human prostaglandin D 2 receptor 1 …

Preparation, structure and reactions of glycosylmanganese pentacarbonyl complexes are
discussed. Anomerically pure complexes of pyranosyl and furanosyl complexes were …

To support pharmacokinetic studies, a selective and sensitive liquid chromatography/tandem
mass spectrometry (LC–MS/MS) method has been developed and validated for the …

Gonadotropin‐releasing hormone (GnRH) receptor antagonists are an important class of
compounds designed to block the pituitary gland from synthesizing follicle‐stimulating …