We present a further development in the technology of sequencing by hybridization to
oligonucleotide microchips (SHOM) and its application to diagnostics for genetic diseases. A robot …

The complexity of human biology requires a systems approach that uses computational
approaches to integrate different data types. Systems biology encompasses the complete …

The challenge of predicting the metabolism or toxicity of a drug in humans has been
approached using in vivo animal models, in vitro systems, high throughput genomics and …

We developed a computational algorithm for evaluating the possibility of cytochrome P450-mediated
metabolic transformations that xenobiotics molecules undergo in the human body. …

Abstract Analysis of microarray, SNPs, proteomics, and other high-throughput (OMICs) data
is challenging because of its biological complexity and high level of technical and biological …

There is an urgent requirement within the pharmaceutical and biotechnology industries,
regulatory authorities and academia to improve the success of molecules that are selected for …

Two procedures, multibase and multiprimer, have been developed for single nucleotide
extension of primers immobilized within polyacrylamide gel pads on a microchip. In the …

The efficiency of sequencing by hybridization to an oligonucleotide microchip grows with an
increase in the number and in the length of the oligonucleotides; however, such increases …

Oligonucleotide microchips are manufactured by immobilizing presynthesized oligonucleotides
within 0.1 × 0.1 × 0.02 mm or 1 × 1 × 0.02 mm polyacrylamide gel pads arranged on the …

We identified a set of genes with an unexpected bimodal distribution among breast cancer
patients in multiple studies. The property of bimodality seems to be common, as these genes …