[HTML][HTML] CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

…, BF Lu, RA Harris, PU Magnusson, E Brittebo… - Journal of …, 2012 - Springer
Background Multiple sclerosis (MS) is an autoimmune disease of the central nervous system
(CNS). In the murine experimental autoimmune encephalomyelitis (EAE) model of MS, T …

Low levels of the air pollutant 1-nitropyrene induce DNA damage, increased levels of reactive oxygen species and endoplasmic reticulum stress in human endothelial …

H Andersson, E Piras, J Demma, B Hellman, E Brittebo - Toxicology, 2009 - Elsevier
Both epidemiological and experimental studies suggest that exposure to high levels of air
pollution is a risk factor associated with cardiovascular disease. Traffic emission is a major …

Transfer of dopamine in the olfactory pathway following nasal administration in mice

…, U Bergman, B Jansson, E Björk, E Brittebo - Pharmaceutical …, 2000 - Springer
Purpose. The aim of the study was to investigate whetherdopamine is transferred along the
olfactory pathway to the brain followingnasal administration to mice. Methods. [ 3 H]-…

Transfer of morphine along the olfactory pathway to the central nervous system after nasal administration to rodents

…, B Jansson, U Bergström, M Dahlin, E Brittebo… - European journal of …, 2005 - Elsevier
The aim of this study was to investigate whether morphine can be transferred along the
olfactory pathway to the CNS, thereby circumventing the blood–brain barrier, after nasal …

Selective Brain Uptake and Behavioral Effects of the Cyanobacterial Toxin BMAA (β-N-Methylamino-L-alanine) following Neonatal Administration to Rodents

O Karlsson, NG Lindquist, EB Brittebo… - Toxicological …, 2009 - academic.oup.com
Cyanobacteria are extensively distributed in terrestrial and aquatic environments all over
the world. Most cyanobacteria can produce the neurotoxin β-N-methylamino-L-alanine (BMAA), …

Early hippocampal cell death, and late learning and memory deficits in rats exposed to the environmental toxin BMAA (β-N-methylamino-L-alanine) during the …

O Karlsson, E Roman, AL Berg, EB Brittebo - Behavioural brain research, 2011 - Elsevier
We have reported previously that exposure to the cyanobacterial neurotoxin β-N-methylamino-l-alanine
(BMAA) during the neonatal period causes cognitive impairments in adult rats. …

Retention of the cyanobacterial neurotoxin βN‐methylamino‐l‐alanine in melanin and neuromelanin‐containing cells – a possible link between Parkinson …

O Karlsson, C Berg, EB Brittebo… - Pigment cell & …, 2009 - Wiley Online Library
β‐N‐methylamino‐l‐alanine (BMAA), a neurotoxic amino acid produced by cyanobacteria,
has been suggested to be involved in the etiology of a neurodegenerative disease complex …

Neonatal exposure to the cyanobacterial toxin BMAA induces changes in protein expression and neurodegeneration in adult hippocampus

…, J Bergquist, NG Lindquist, EB Brittebo… - Toxicological …, 2012 - academic.oup.com
The cyanobacterial toxin β-N-methylamino-l-alanine (BMAA) has been proposed to contribute
to neurodegenerative disease. We have previously reported a selective uptake of BMAA …

Long-term Cognitive Impairments in Adult Rats Treated Neonatally with β-N-Methylamino-L-Alanine

O Karlsson, E Roman, EB Brittebo - Toxicological Sciences, 2009 - academic.oup.com
Most cyanobacteria (blue-green algae) can produce the neurotoxin β-N-methylamino-L-alanine
(BMAA). Dietary exposure to BMAA has been suggested to be involved in the etiology of …

Methimazole toxicity in rodents: covalent binding in the olfactory mucosa and detection of glial fibrillary acidic protein in the olfactory bulb

U Bergman, EB Brittebo - Toxicology and applied pharmacology, 1999 - Elsevier
Methimazole is an antithyroid drug reported to affect the sense of smell and taste in humans.
The aim of the present study was to examine the distribution and effects of methimazole on …