Selective serotonin reuptake inhibitors and cytochrome P-450 mediated drug-drug interactions: an update
A Hemeryck, FM Belpaire - Current drug metabolism, 2002 - ingentaconnect.com
The selective serotonin reuptake inhibitors (SSRIs) have become the most prescribed
antidepressants in many countries. Although the SSRIs share a common mechanism of action, …
antidepressants in many countries. Although the SSRIs share a common mechanism of action, …
Pharmacokinetic and pharmacodynamic considerations when treating patients with sepsis and septic shock
P De Paepe, FM Belpaire, WA Buylaert - Clinical pharmacokinetics, 2002 - Springer
Sepsis and septic shock are accompanied by profound changes in the organism that may
alter both the pharmacokinetics and the pharmacodynamics of drugs. This review elaborates …
alter both the pharmacokinetics and the pharmacodynamics of drugs. This review elaborates …
Metformin treatment in patients with type 2 diabetes and chronic kidney disease stages 3A, 3B, or 4
…, Y Bennis, AS Hurtel-Lemaire, F Belpaire… - Diabetes …, 2018 - Am Diabetes Assoc
OBJECTIVE This study was conducted to define a safe, effective dose regimen for metformin
in moderate and severe chronic kidney disease (CKD; stages 3A/3B and 4, respectively), …
in moderate and severe chronic kidney disease (CKD; stages 3A/3B and 4, respectively), …
Cytochrome P450: genetic polymorphism and drug interactions
FM Belpaire, MG Bogaert - Acta Clinica Belgica, 1996 - Taylor & Francis
In this review, after a short discussion of our knowledge about cytochrome P450 isoenzymes,
two important sources of variability in the metabolism of drugs by cytochrome P450 are …
two important sources of variability in the metabolism of drugs by cytochrome P450 are …
Paroxetine affects metoprolol pharmacokinetics and pharmacodynamics in healthy volunteers
…, C De Vriendt, FM Belpaire - Clinical …, 2000 - Wiley Online Library
Objective To investigate the effect of multiple‐dose paroxetine intake on the stereoselective
pharmacokinetics and the pharmacodynamics of metoprolol. Methods We conducted an …
pharmacokinetics and the pharmacodynamics of metoprolol. Methods We conducted an …
The oxidative metabolism of metoprolol in human liver microsomes: inhibition by the selective serotonin reuptake inhibitors
FM Belpaire, P Wijnant, A Temmermann… - European journal of …, 1998 - Springer
Objective: Biotransformation of metoprolol to α-hydroxymetoprolol (HM) and O-demethylmetoprolol
(ODM) is mediated by CYP2D6. The selective serotonin reuptake inhibitors (SSRIs) …
(ODM) is mediated by CYP2D6. The selective serotonin reuptake inhibitors (SSRIs) …
Inhibition of CYP2C9 by selective serotonin reuptake inhibitors: in vitro studies with tolbutamide and (S)-warfarin using human liver microsomes
A Hemeryck, C De Vriendt, FM Belpaire - European journal of clinical …, 1999 - Springer
Objective: To investigate the in vitro potential of selective serotonin reuptake inhibitors (SSRIs)
to inhibit two CYP2C9-catalysed reactions, tolbutamide 4-methylhydroxylation and (S)-…
to inhibit two CYP2C9-catalysed reactions, tolbutamide 4-methylhydroxylation and (S)-…
Is vitreous humour useful for the interpretation of 3, 4-methylenedioxymethamphetamine (MDMA) blood levels? Experimental approach with rabbits
…, P De Paepe, KM Clauwaert, FM Belpaire… - International Journal of …, 2000 - Springer
As drug instability and redistribution are factors known to affect the interpretation of post-mortem
blood levels, we questioned whether post-mortem vitreous humour concentrations could …
blood levels, we questioned whether post-mortem vitreous humour concentrations could …
Tissue fractionation and catecholamines—II: Intracellular distribution patterns of tyrosine hydroxylase, dopa decarboxylase, dopamine-β-hydroxylase …
P Laduron, F Belpaire - Biochemical Pharmacology, 1968 - Elsevier
The intracellular localization of several enzymes involved in the biosynthesis and metabolism
of the catecholamines was investigated in bovine adrenal medulla. Various fractions …
of the catecholamines was investigated in bovine adrenal medulla. Various fractions …
Binding ofβ-adrenoceptor blocking drugs to human serum albumin, to α1-acid glycoprotein and to human serum
FM Belpaire, MG Bogaert, M Rosseneu - European journal of clinical …, 1982 - Springer
The binding of 8 β-adrenergic blocking drugs to human serum albumin, to α 1 -acid glycoprotein
and to serum from normal volunteers and from patients with rheumatoid arthritis was …
and to serum from normal volunteers and from patients with rheumatoid arthritis was …