The production of arginomycin was followed by paper chromatography using a variety of
mobile phases. The Rf values of arginomycin in the following solvents were: 0.00 [1-butanol-…

The thiophene moiety is considered a structural alert in molecular design in drug discovery,
largely because several thiophene-containing drugs, including tienilic acid and suprofen, …

2HNMRspectra wererecorded on a Varian XL-200spectrometer operating at 200MHz.
Solutions (ca. 0.4 ml, ca. 0.25 m) of the compounds in dimethyl sulfoxide-d6 or acetone-^ were …

Spectroscopic Methods UVspectra were obtained in methanol using a Perkin-Elmer
Lambda7 spectrophotometer. IR spectra were run in Nujol mull using a Digilab FTS-ISEspectrometer…

The production of paulomycins' was followed by TLCon Silica gel Gusing chloroform-ethanolwater
(25: 30: 5) or chloroform-MeOH (90: 10) as the solvent system. Paulomycins were …

RATIONALE Herein we describe a generic quantitative method using high‐resolution,
isotope‐dilution (HRID) metabolism of isotope‐labeled compounds and apply it to the analysis of …

In the process of drug design, it is important to consider potential structural alerts that may
lead to toxicosis. This work illustrates how using trifluoroethane as a part of a novel chemical …

The quinuclidine PHA-0568487 (1) is an agonist of the alpha 7 nicotinic acetylcholine
receptor that was designed to mitigate the bioactivation associated with the core scaffold and …

Table 1 shows the effect of various concen-trations of methionine on production of paulo-mycin
C in fermentations of S. paulus. A fermentation containing noaddedprecursor was …

Aas the TLCsystem mentionedearlier andtherefore to separate easily frompaulomycin. The
production of the paulomycin complex by S. paulus strain 273 (UC 5142, NRRL12251) and …