Pharmacokinetics of azithromycin in rats and dogs

RM Shepard, FC Falkner - Journal of Antimicrobial …, 1990 - academic.oup.com
After intravenous or oral administration to rats and dogs, azithromycin was rapidly distributed
into the tissues, where concentrations frequently exceeded those in serum by 100-fold or …

Discovery of the Hemifumarate and (α-l-Alanyloxy)methyl Ether as Prodrugs of an Antirheumatic Oxindole:  Prodrugs for the Enolic OH Group

…, R Destito, KM Donahue, FC Falkner… - Journal of Medicinal …, 1996 - ACS Publications
Ether, ester, and carbonate derivatives of the antirheumatic oxindole 1 were prepared and
screened as potential prodrugs of 1. This effort led to the discovery of the (α-l-alanyloxy)…

Ampiroxicam, an anti-inflammatory agent which is a prodrug of piroxicam

TJ Carty, A Marfat, PF Moore, FC Falkner… - Agents and Actions, 1993 - Springer
Ampiroxicam is a nonacidic ether carbonate prodrug of piroxicam. Our results demonstrate
that, in contrast to piroxicam, ampiroxicam does not possess detectable prostaglandin …

Biomedical applications of selected ion monitoring

FC Falkner, BJ Sweetman… - Applied Spectroscopy …, 1975 - Taylor & Francis
In 1961 Henneberg [1] employed selected ion monitoring (SIM) to study hydrocarbons
eluting from a gas chromatographic column, and in 1966 the first biological application was …

Disposition and metabolism of tenidap in the rat

HG Fouda, MJ Avery, D Dalvie, FC Falkner… - Drug metabolism and …, 1997 - ASPET
Tenidap is a new antirheumatic drug currently undergoing clinical evaluation. It inhibits
production and activity of cytokines in vivo and causes significant reductions in plasma markers …

Metabolism of digitoxin in man and its modification by spironolactone

KE Wirth, JC Frölich, JW Hollifield, FC Falkner… - European Journal of …, 1976 - Springer
The effect of spironolactone on the metabolism of intravenously administered 3 H-digitoxin (80
µCi) was investigated in eight patients. In three of them the labelled glycoside was given …

Quantitative determination of guanethidine and other guanido-containing drugs in biological fluids by gas chromatography with flame ionization detection and multiple …

JH Hengstmann, FC Falkner, JT Watson… - Analytical …, 1974 - ACS Publications
Method. An outline of the procedure is presented in Figure 1. Briefly, the method involves
addition of an internal standard, ad-justment of the pH to 10, and preliminary extraction with …

Disposition of ampiroxicam, a prodrug of piroxicam, in man

FC Falkner, TM Twomey, AP Borger, D Garg… - Xenobiotica, 1990 - Taylor & Francis
1. Ampiroxicam, a prodrug of the effective anti-inflammatory agent piroxicam, was completely
converted to piroxicam after oral administration to man. 2. At clinical doses there was no …

Simultaneous determination of tenidap and its stable isotope analog in serum by high‐performance liquid chromatography/atmospheric pressure chemical ionization …

MJ Avery, DY Mitchell, FC Falkner… - Biological mass …, 1992 - Wiley Online Library
A specific high‐performance liquid chromatographic/atmospheric pressure chemical ionization
tandem mass spectrometric assay for the quantitative determination of tenidap and its D 3 …

In vitro/in vivo correlations of sustained-release coated multiparticulate formulations of doxazosin

AG Thombre, AR DeNoto, FC Falkner… - International journal of …, 1994 - Elsevier
Sustained-release coated multiparticulates of doxazosin were prepared by layering the
drug onto nonpareil seeds and then coating these drug-layered beads with a rate-controlling …