Importance Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized
for COVID-19 have variously reported benefit, no effect, and harm. Objective To estimate the …

Background Concerns have been raised about the possibility that inhibitors of the renin–angiotensin–aldosterone
system (RAAS) could predispose individuals to severe COVID-19; …

Neutrophils eliminate pathogens efficiently but can inflict severe damage to the host if they
over-activate within blood vessels. It is unclear how immunity solves the dilemma of mounting …

The discovery of reliable biomarkers to predict efficacy and toxicity of anticancer drugs
remains one of the key challenges in cancer research. Despite its relevance, no efficient study …

Several cytochrome P450 (CYP) CYP3A polymorphisms were associated with reduced
enzyme function. We aimed to evaluate the influence of these alleles on the pharmacokinetic …

Psoriasis (Ps) is a chronic inflammatory disease with an important genetic component. It
shares pathophysiological mechanisms with other autoimmune diseases such as psoriatic …

Background We aimed to determine the impact of tocilizumab use on severe COVID-19 (coronavirus
disease 19) pneumonia mortality. Methods We performed a multicentre …

ApTOLL is an aptamer that antagonizes Toll-like receptor 4 and improves functional
outcomes in models of ischemic stroke and myocardial infarction. The aim of this study was to …

Psoriasis is a chronic inflammatory disease of the skin. The causes of psoriasis are unknown,
although family and twin studies have shown genetic factors to play a key role in its …

Background Antitumour necrosis factor (anti‐TNF)‐α agents can be used successfully to treat
patients with psoriasis and other inflammatory diseases. However, very few studies have …