Enantioselective aspects of drug action and disposition: therapeutic pitfalls
From a historical perspective, chemists have been most conversant with stereochemical
principles and the complex mixtures which occur when organic compounds, including drugs, …
principles and the complex mixtures which occur when organic compounds, including drugs, …
A systematic review of remuneration systems for clinical pharmacy care services
…, KA Grindrod, D Bougher, FM Pasutto… - … Journal/Revue des …, 2008 - journals.sagepub.com
Objective: To provide descriptions of existing remuneration models for pharmacist clinical
care services and to summarize the existing evaluations of economic, clinical, and humanistic …
care services and to summarize the existing evaluations of economic, clinical, and humanistic …
Inhibition of insulin metabolism by hydroxychloroquine and its enantiomers in cytosolic fraction of liver homogenates from healthy and diabetic rats
To elucidate the mechanism by which hydroxychloroquine (HCQ) affects glucose metabolism,
the effect of this drug and its enantiomers on insulin metabolism was studied using the …
the effect of this drug and its enantiomers on insulin metabolism was studied using the …
Pharmacokinetics of ibuprofen enantiomers in humans following oral administration of tablets with different absorption rates
F Jamali, NN Singh, FM Pasutto, AS Russell… - Pharmaceutical …, 1988 - Springer
Ibuprofen (IB) is a racemic drug and is administered as such. While activity is due mainly to
the S enantiomer, pharmacokinetic interpretations, as well as criteria to assess the …
the S enantiomer, pharmacokinetic interpretations, as well as criteria to assess the …
Analytical and semi-preparative high-performance liquid chromatographic separation and assay of hydroxychloroquine enantiomers
(±)-Hydroxychloroquine (HCQ) is an antimalarial and anti-arthritic drug which is
administered as the racemate. An accurate, precise and sensitive high-performance liquid …
administered as the racemate. An accurate, precise and sensitive high-performance liquid …
Gas chromatographic analysis of trace phenols by direct acetylation in aqueous solution
RT Coutts, EE Hargesheimer, FM Pasutto - Journal of Chromatography A, 1979 - Elsevier
Acetate esters of six phenolics were formed by the direct addition of 500 μl acetic anydride
to 250 ml of a dilute aqueous phenolic solution containing 10 g sodium bicarbonate. In the …
to 250 ml of a dilute aqueous phenolic solution containing 10 g sodium bicarbonate. In the …
Liquid-chromatographic assay of ibuprofen enantiomers in plasma.
This stereospecific "high-performance" liquid-chromatographic (HPLC) assay is suitable for
pharmacokinetic studies of ibuprofen (IB). Very efficient extraction of the drug and internal …
pharmacokinetic studies of ibuprofen (IB). Very efficient extraction of the drug and internal …
Simultaneous extraction and quantitation of several bioactive amines in cheese and chocolate
GB Baker, JTF Wong, RT Coutts, FM Pasutto - Journal of Chromatography A, 1987 - Elsevier
A method is described for simulataneous extractoin and quantitation of the amines 2-phenylethylamine,
tele-methylhistamine, histamine, tryptamine, m- and p-tyramine, 3-…
tele-methylhistamine, histamine, tryptamine, m- and p-tyramine, 3-…
Gas chromatographic separation of optically active anti-inflammatory 2-arylpropionic acids using (+)-or (−)-amphetamine as derivatizing reagent
NN Singh, FM Pasutto, RT Coutts, F Jamali - Journal of Chromatography B …, 1986 - Elsevier
A method is described for the derivatization of several non-steroidal anti-inflammatory
arylalkanoic acids (ibuprofen, ketoprofen, naproxen, fenoprofen, flurbiprofen, pirprofen, cicloprofen…
arylalkanoic acids (ibuprofen, ketoprofen, naproxen, fenoprofen, flurbiprofen, pirprofen, cicloprofen…
Effect of experimental diabetes mellitus and arthritis on the pharmacokinetics of hydroxychloroquine enantiomers in rats
Purpose. To study the effect of experimental diabetes and arthritis on the pharmacokinetics
of hydroxychloroquine (HCQ) enantiomers in rats. Methods. The pharmacokinetic studies …
of hydroxychloroquine (HCQ) enantiomers in rats. Methods. The pharmacokinetic studies …