Enantioselective aspects of drug action and disposition: therapeutic pitfalls

F Jamali, R Mehvar, FM Pasutto - Journal of pharmaceutical sciences, 1989 - Elsevier
From a historical perspective, chemists have been most conversant with stereochemical
principles and the complex mixtures which occur when organic compounds, including drugs, …

A systematic review of remuneration systems for clinical pharmacy care services

…, KA Grindrod, D Bougher, FM Pasutto… - … Journal/Revue des …, 2008 - journals.sagepub.com
Objective: To provide descriptions of existing remuneration models for pharmacist clinical
care services and to summarize the existing evaluations of economic, clinical, and humanistic …

Inhibition of insulin metabolism by hydroxychloroquine and its enantiomers in cytosolic fraction of liver homogenates from healthy and diabetic rats

J Emami, FM Pasutto, JR Mercer, F Jamali - Life sciences, 1998 - Elsevier
To elucidate the mechanism by which hydroxychloroquine (HCQ) affects glucose metabolism,
the effect of this drug and its enantiomers on insulin metabolism was studied using the …

Pharmacokinetics of ibuprofen enantiomers in humans following oral administration of tablets with different absorption rates

F Jamali, NN Singh, FM Pasutto, AS Russell… - Pharmaceutical …, 1988 - Springer
Ibuprofen (IB) is a racemic drug and is administered as such. While activity is due mainly to
the S enantiomer, pharmacokinetic interpretations, as well as criteria to assess the …

Analytical and semi-preparative high-performance liquid chromatographic separation and assay of hydroxychloroquine enantiomers

DR Brocks, FM Pasutto, F Jamali - Journal of Chromatography B …, 1992 - Elsevier
(±)-Hydroxychloroquine (HCQ) is an antimalarial and anti-arthritic drug which is
administered as the racemate. An accurate, precise and sensitive high-performance liquid …

Gas chromatographic analysis of trace phenols by direct acetylation in aqueous solution

RT Coutts, EE Hargesheimer, FM Pasutto - Journal of Chromatography A, 1979 - Elsevier
Acetate esters of six phenolics were formed by the direct addition of 500 μl acetic anydride
to 250 ml of a dilute aqueous phenolic solution containing 10 g sodium bicarbonate. In the …

Liquid-chromatographic assay of ibuprofen enantiomers in plasma.

R Mehvar, F Jamali, FM Pasutto - Clinical chemistry, 1988 - academic.oup.com
This stereospecific "high-performance" liquid-chromatographic (HPLC) assay is suitable for
pharmacokinetic studies of ibuprofen (IB). Very efficient extraction of the drug and internal …

Simultaneous extraction and quantitation of several bioactive amines in cheese and chocolate

GB Baker, JTF Wong, RT Coutts, FM Pasutto - Journal of Chromatography A, 1987 - Elsevier
A method is described for simulataneous extractoin and quantitation of the amines 2-phenylethylamine,
tele-methylhistamine, histamine, tryptamine, m- and p-tyramine, 3-…

Gas chromatographic separation of optically active anti-inflammatory 2-arylpropionic acids using (+)-or (−)-amphetamine as derivatizing reagent

NN Singh, FM Pasutto, RT Coutts, F Jamali - Journal of Chromatography B …, 1986 - Elsevier
A method is described for the derivatization of several non-steroidal anti-inflammatory
arylalkanoic acids (ibuprofen, ketoprofen, naproxen, fenoprofen, flurbiprofen, pirprofen, cicloprofen…

Effect of experimental diabetes mellitus and arthritis on the pharmacokinetics of hydroxychloroquine enantiomers in rats

J Emami, FM Pasutto, F Jamali - Pharmaceutical research, 1998 - Springer
Purpose. To study the effect of experimental diabetes and arthritis on the pharmacokinetics
of hydroxychloroquine (HCQ) enantiomers in rats. Methods. The pharmacokinetic studies …