Alendronate is an antiosteolytic agent under investigation for the treatment of a number of
bone disorders. Since the compound is a zwitterion with five pK a values and is completely …

Caspofungin acetate (MK-0991) is a semisynthetic pneumocandin derivative being developed
as a parenteral antifungal agent with broad-spectrum activity against systemic infections …

Indinavir, a potent and specific inhibitor of HIV protease, is a known substrate of cytochrome
P-450 (CYP) 3A and p-glycoprotein. The purpose of this study is to investigate and compare …

Efavirenz (EFV, Sustiva, Stocrin, DMP-266, L-743,726) is a potent and selective non-nucleoside
inhibitor of HIV-1 reverse transcriptase. Pharmacokinetics of EFV was studied in rats …

Alendronate (4-amino-1-hydroxybutylidene-1,1-bisphosphonate), an antiosteolytic agent, is
currently under investigation in the treatment of a variety of bone diseases. Earlier studies …

Alendronate (4-amino-1-hydroxybutylidine-1,1-bisphosphonate), an antiosteolytic agent, is
currently under investigation for the treatment of osteoporosis. Earlier studies in animals from …

Alendronate (4-amino-1-hydroxybutylidene-1,1-bisphosphonate), an antiosteolytic agent, is
currently under investigation in the treatment of osteoporosis. The purpose of this study was …

The plasma protein binding of the enantiomers of MK-571 was stereoselective and the
stereoselectivity was species dependent. The 12 mammalian species studied could be classified …

L-754,394, a furanopyridine derivative, is an experimental HIV protease inhibitor. Previous
studies from this laboratory have demonstrated that L-754,394 is cleared very rapidly in …

The disposition of caspofungin, a parenteral antifungal drug, was investigated. Following a
single, 1-h, intravenous infusion of 70 mg (200 μCi) of [ 3 H]caspofungin to healthy men, …